Transitional cell carcinoma associated with marijuana: Case report and review of the literature

Nieder, Alan M.; Lipke, Michael C.; Madjar, Shahar

doi:10.1016/j.urology.2005.08.006

Cited by 22 publications

(19 citation statements)

References 10 publications

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“…Hashibe et al 12 conducted a study on 2252 subjects, including people with and without cancer, and found no relationship between cannabis use and lung and aerodigestive tract cancers. Some authors have hypothesized that cannabis use might be a cause of transitional cell carcinoma, a type of bladder cancer typically associated with tobacco smokers13,14. Hall et al 15 reviewed the relationships between cancer and cannabis, including its possible role as a cause of cancer and its use to relieve pain in cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Bogarting that Joint Might Decrease Oral hpv among Cannabis Users

Zwenger

2009

Current Oncology

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Human papilloma virus (hpv) has many known strains, two of the most well studied perhaps being the high-risk types 16 and 18. These strains have attracted more interest because they are known to disrupt tumour-suppressor genes that control the cell cycle, rendering those genes less effective at keeping cell division in check.Within the last decade, an increase in oral hpv–linked cancers of the throat and tongue has been attributed to exposure and contraction of hpv through oral sex, most notably in younger people. An understudied and arguably equal contributor to oral hpv infection might be indirect contact with an infected person. Presented here is a brief but important perspective on the relationship between cannabis use and oral cancer. The development of oral cancer is not a result of smoking cannabis per se; rather, it is hypothesized to be a result of contracting hpv through various forms of sharing and passing joints and other smoking apparatuses. Therefore, it is hypothesized that bogarting (and not passing) joints might decrease oral hpv among cannabis smokers. Future research should therefore investigate the prevalence of oral hpv in cannabis smokers to better understand its epidemiology.

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Section: Discussionmentioning

confidence: 99%

Bogarting that Joint Might Decrease Oral hpv among Cannabis Users

Zwenger

2009

Current Oncology

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“…[24][25][26] The largest study to date is a retrospective case series analyzing cannabis use among 52 men aged <60 years of age diagnosed with bladder cancer. 24 The men completed questionnaires on cannabis use and were then compared to age-matched controls who were also questioned on cannabis use.…”

Section: Commentmentioning

confidence: 99%

“…Despite the paucity of literature exploring the association of cannabis use and the development of bladder cancer, 25,26 there are several studies characterizing the effects of cannabis use on bladder function. Initially, anecdotal reports from patients with multiple sclerosis suggested that cannabis use alleviated bothersome lower urinary tract symptoms.…”

Section: Commentmentioning

confidence: 99%

Association Between Cannabis Use and the Risk of Bladder Cancer: Results From the California Men's Health Study

Thomas

Wallner

Quinn

et al. 2015

Urology

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“…Similarly, Reena et al (2006) found alveolar macrophage dysfunc-tion and bronchial mucosal histopathologic abnormalities in the lungs of marijuana smokers. The epidemiological literature includes studies on various cancers related to marijuana smoke, for example, head and neck cancers (Zhang et al, 1999), lung and upper aerodigestive tract cancers (Hashibe et al, 2006), oral squamous cell carcinoma (Rosenblatt et al, 2004), transitional cell carcinoma (Moiche et al, 2001;Chacko et al, 2006;Nieder et al, 2006), and respiratory tract cancers (Taylor, 1988), but discrepancies still exist in the epidemiological results, thus, a strong association between marijuana smoke and cancer has not yet been determined.…”

Section: Introductionmentioning

confidence: 99%

Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells

et al. 2013

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Since the largely abused worldwide used of marijuana, there have been many ongoing debates regarding the adverse health effects of marijuana smoking. Marijuana smoking was recently proved to cause pulmonary toxicity by inducing genotoxic effects or generating reactive oxygen species. Because p53, a tumor suppressor gene, has an important pathophysiologic role in the regulation of lung epithelial cell DNA damage responses, we hypothesized that p53 may be involved in the oxidative stress-mediated apoptosis induced by marijuana smoking. First, we confirmed that marijuana smoke condensate (MSC) induces oxidative stress in BEAS-2B cells. We observed that reactive oxygen species (ROS) generation was increased by MSC in the DCFH-DA assay. Also, antioxidant enzyme (superoxide dismutase, catalase) activity and their mRNA expressions were up-regulated by MSC. Second, we investigated p53 involvement in the MSC-induced apoptotic pathway in BEAS-2B cells. The results showed that MSC increased caspase-3 activation and DNA fragmentation as markers of apoptosis. In addition, the mRNA levels of apoptosis-related genes (p53 and Bax) were increased by MSC and phospho-p53, along with the increase of Bax protein expression by MSC. Apoptosis and apoptosis-related gene expression were partially blocked by an inhibitor of p53-dependent transcriptional activation (pifithrin-α). The results indicate that p53 plays a role in MSC-induced apoptosis. Taken together, the findings of the present study suggest that MSC partially induces p53-mediated apoptosis through ROS generation in human lung epithelial cells and this may have broader implications for our understanding of pulmonary diseases.

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Transitional cell carcinoma associated with marijuana: Case report and review of the literature

Cited by 22 publications

References 10 publications

Bogarting that Joint Might Decrease Oral hpv among Cannabis Users

Bogarting that Joint Might Decrease Oral hpv among Cannabis Users

Association Between Cannabis Use and the Risk of Bladder Cancer: Results From the California Men's Health Study

Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells

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