Transitional Care for Children with Neurologic Disorders

Camfield, Carol; Camfield, Peter; Brown, Lawrence W.

doi:10.1016/b978-0-323-37101-8.00165-x

Cited by 1 publication

(1 citation statement)

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“…Neurocognitive impairments occur among patients with CS with the extent of the impairment being more severe among patients with SCS. 7,8 Neurological sequelae are believed to stem from the rapidly growing brain being constricted by the cranium. 9 Exploring the intracranial volume (ICV)-to-cortical surface area (CSA) relationship among patients with SCS and controls, Wilson et al determined that patients with fibroblast growth factor receptors (FGFR)-mediated SCS (ie, Crouzon, Apert, Saethre-Chotzen syndrome) had significantly greater ICV than controls ( P < .001).…”

Section: Introductionmentioning

confidence: 99%

Are Patients With Syndromic Craniosynostosis at Greater Risk for Abnormal Speech and Language Development Than Patients With Non-syndromic Craniosynostosis?

Stanbouly,

Goudarzi,

Grillo

et al. 2023

FACE

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Objective: The aim of this study was to determine whether patients with syndromic craniosynostosis (SCS) are at increased risk for abnormal speech and language development (ASLD) relative to patients with non-syndromic craniosynostosis (NSCS). Study Design: A retrospective cohort study was completed using the Kids’ Inpatient Database (KID). All patients with craniosynostosis (CS) were included were included. The primary predictor variable was study grouping (SCS vs NSCS). The primary outcome variable was ASLD. Multivariate logistic regression were performed to identify risk factors for ASLD. Results: The final study sample included a total of 10 089 patients with craniosynostosis (CS) (37.7% female, 51.6% White, mean age 1.78 years). Patients with SCS were at increased risk for ASLD relative to patients with NSCS (OR 2.1, P < .001). After controlling for all other variables, patients with SCS were no longer at increased risk for ASLD relative to patients with NSCS (OR 1.2, P = .442). Conclusions: Relative to NSCS, SCS per se is not a risk factor for ASLD. The significantly greater prevalence of asthma, intracranial hypertension, and compression of brain, all of which are risk factors for ASLD, among patients with SCS explains the greater prevalence of ASLD in SCS relative to NSCS.

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Section: Introductionmentioning

confidence: 99%