Transition over 35 Years in the Incidence Rates of Primary Central Nervous System Tumors in Shanghai, China and Histological Subtyping Based on a Single Center Experience Spanning 60 Years

Shen, Fang; Wu, Chunxiao; Yao, Yu; Peng, Peng; Qin, Zhiyong; Yin, Wenwu; Ying, Zheng; Zhou, Lei

doi:10.7314/apjcp.2013.14.12.7385

Cited by 8 publications

(9 citation statements)

References 32 publications

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“…In China, the first report on CNS tumors, published in 1982, indicated that neuroepithelial and meningeal tumors were first and second in terms of frequency of occurrence and that the age distribution of Chinese patients with CNS tumors was lower than that of Caucasians with CNS tumors [4]. Between 1973 and 2007, there was a steady increase in the 5-year, age-adjusted incidence rate in both males (from 3.5 to 5.88/100 000) and females (from 3.03 to 7/100 000) in Shanghai, China [5]. Malignant brain tumors and even histologically benign tumors can endanger patient survival and cause severe neurological dysfunction because of their space-occupying effects and occasional transformation to malignancy.…”

Section: Introductionmentioning

confidence: 94%

Prevalence and associated positive psychological variables of anxiety and depression among patients with central nervous system tumors in China: a cross‐sectional study

Bao

Guan

et al. 2016

Psycho-Oncology

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Background: Anxiety and depression have been identified as common psychological distresses faced by the majority of patients with cancer. However, no studies have investigated the relationship between positive psychological variables (hope, optimism and general self-efficacy) and anxiety and depression among patients with central nervous system (CNS) tumors in China. Our hypothesis is that the patients with higher levels of hope, optimism or general self-efficacy have lower levels of anxiety and depression when encountered by stressful life events such as CNS tumors.Methods: Questionnaires, including the Hospital Anxiety and Depression Scale, the Herth Hope Index, the Life Orientation Scale-Revised and the General Self-Efficacy Scale, and demographic and clinical records were used to collect information about patients with CNS tumors in Liaoning Province, China. The study included 222 patients (effective response rate: 66.1%). Hierarchical linear regression analyses were performed to explore the associations among hope, optimism, general selfefficacy and anxiety/depression.Results: Prevalence of anxiety and depression were 42.8 and 32.4%, respectively, among patients with CNS tumors. Hope and optimism both were negatively associated with anxiety and together accounted for 21.4% of variance in anxiety. Similarly, hope and optimism both were negatively associated with depression and accounted for 32.4% of variance in depression.Conclusions: The high prevalence of anxiety and depression among patients with CNS tumors should receive more attention in Chinese medical settings. To help reduce anxiety and depression, health care professionals should develop interventions to promote hope and optimism based on patients' specific needs.

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Section: Introductionmentioning

confidence: 94%

Prevalence and associated positive psychological variables of anxiety and depression among patients with central nervous system tumors in China: a cross‐sectional study

Bao

Guan

et al. 2016

Psycho-Oncology

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“…2 All siRNA sequences were synthesized by GenePharma (Shanghai, China). 2 All siRNA sequences were synthesized by GenePharma (Shanghai, China).…”

Section: Small Interfering Rna and Recombinant Plasmid Transfectionmentioning

confidence: 99%

Long noncoding RNA growth arrest‐specific 5 facilitates glioma cell sensitivity to cisplatin by suppressing excessive autophagy in an mTOR‐dependent manner

Huo

Chen

2018

J of Cellular Biochemistry

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Malignant glioma is a severe type of brain tumor with a grim prognosis. The occurrence of resistance compromises the efficacy of chemotherapy for glioma. Long noncoding RNA growth arrest‐specific 5 (GAS5) has recently become an attractive target for cancer therapy by regulating cell growth, invasion, and migration. Nevertheless, its role in glioma chemoresistance remains elusive. In the current study, the expression of GAS5 was decreased in glioma cell lines, and lower levels of GAS5 were observed in U138 and LN18 glioma cells that had low sensitivity to cisplatin. Functional assay confirmed that knockdown of GAS5 enhanced cell resistance to cisplatin in U87 cells, which had a relatively high expression of GAS5. Conversely, elevation of GAS5 increased cell sensitivity to cisplatin in U138 cells that had a relatively low expression of GAS5. Mechanistically, cisplatin exposure evoked excessive autophagy concomitant with an increase in autophagy‐related LC3II expression and a decrease in autophagy substrate p62 expression, which was reversely muted after GAS5 overexpression. In addition, GAS5 restored cisplatin‐inhibited mammalian target of rapamycin (mTOR) activation. Preconditioning with mTOR antagonist rapamycin engendered not only mTOR inhibition but also abrogated GAS5‐mediated depression in cisplatin‐evoked autophagy. Notably, blocking the mTOR pathway also attenuated GAS5‐increased sensitivity to cisplatin in U138 cells. Cumulatively, these findings indicate that GAS5 may blunt the resistance of glioma cells to cisplatin by suppressing excessive autophagy through the activation of mTOR signaling, implying a promising therapeutic strategy against chemoresistance in glioma.

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“…7 In addition, their distribution varies throughout the world, with the highest incidence in Australia, North America and European countries (men, 5.8 per 100,000; women, 4.1 per 100,000), especially among the white people, and the lowest in Africa (men, 3.0 per 100,000; women, 2.1 per 100,000). 8,9 Epidemiological studies in different parts of the world have shown that males have a higher risk of being diagnosed with malignant brain and other CNS tumors than females. 10 It is estimated that about 50,800 new cancer cases occur in Iran each year.…”

Section: Introductionmentioning

confidence: 99%

Spatio-temporal pattern of malignant neoplasm of brain in Fars province I.R.Iran (2011–2015): A population-based cross sectional study

Rezaianzadeh¹,

Jafari

Khosravizadegan³

et al. 2020

Clinical Epidemiology and Global Health

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Background: Tumors of the central nervous system (CNS) are a heterogeneous group of neoplasms with different prevalence in different genders, age groups and various parts of the CNS. This study aimed to investigate the incidence of malignant neoplasm of brain (C71) based on Fars population data. Methods: This study was cross-sectional, carried out based on Fars population -based Cancer Registry (FPCR) data. Data was collected retrospectively reviewing all malignant neoplasm of brain patients' records during a 5year period (2011)(2012)(2013)(2014)(2015). Age Standardized Incidence Rates (ASR) were calculated based on world population standards. To analyze the ASR time trends by gender, we carried out a chi-square goodness of fit test. Results: Findings revealed that 1043 cases of malignant neoplasm of brain were registered, 438 (%41.9) of which were women. Malignant neoplasm of brain became the eighth malignancy in 2015 in both genders. Its incidence was higher in men (26.15/100000) than in women (19.45/100 000). There was an increasing but not significant trend from 2011 to 2013 in both men and women (p = 0.722, p = 0.478, respectively). The highest increase was in 2013 (ASR = 6.64 in men and ASR = 5.71 in women per 100,000). Conclusion: Brain and other CNS tumors are an important source of cancer deaths around the world. Regional variations in incidence may provide clues leading to genetic and/or environmental causes as well as a basis for expanding knowledge about their epidemiology. This study demonstrated that the trend had been increasing in the years during which the study was conducted.

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Transition over 35 Years in the Incidence Rates of Primary Central Nervous System Tumors in Shanghai, China and Histological Subtyping Based on a Single Center Experience Spanning 60 Years

Cited by 8 publications

References 32 publications

Prevalence and associated positive psychological variables of anxiety and depression among patients with central nervous system tumors in China: a cross‐sectional study

Prevalence and associated positive psychological variables of anxiety and depression among patients with central nervous system tumors in China: a cross‐sectional study

Long noncoding RNA growth arrest‐specific 5 facilitates glioma cell sensitivity to cisplatin by suppressing excessive autophagy in an mTOR‐dependent manner

Spatio-temporal pattern of malignant neoplasm of brain in Fars province I.R.Iran (2011–2015): A population-based cross sectional study

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