Transition of Extremely Low-Birth-Weight Infants From Adolescence to Young Adulthood

Saigal, Saroj; Stoskopf, Barbara; Streiner, David L.; Boyle, Michael; Pinelli, Janet; Paneth, Nigel; Goddeeris, John H.

doi:10.1001/jama.295.6.667

Cited by 209 publications

(106 citation statements)

References 42 publications

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“…A total of 83 (74%) of 113 NBW adults participated in the study. The 154 ELBW and NBW participants in the present study were part of a larger study examining transition into young adulthood, 17 health states, 18 and quality of life 19 of individuals born with ELBW.…”

Section: Participants and Sample Overviewmentioning

confidence: 99%

Shyness and Timidity in Young Adults Who Were Born at Extremely Low Birth Weight

Schmidt

Miskovic

Boyle³

et al. 2008

Pediatrics

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104

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Section: Participants and Sample Overviewmentioning

confidence: 99%

Shyness and Timidity in Young Adults Who Were Born at Extremely Low Birth Weight

Schmidt

Miskovic

Boyle³

et al. 2008

Pediatrics

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104

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“…6,7 Preliminary studies of auditory tasks in children who were born prematurely suggest the presence of aberrant systems for language at school age, 5,8 yet recent neuropsychological studies document improvement in testing scores and school performance with time in children who were born prematurely. [9][10][11][12] We previously reported in a study of almost 300 children born weighing 600 to 1250 g that the median Peabody Picture Vocabulary Test-Revised (PPVT-R) score, a standard measure for receptive vocabulary, increased from 88 at 3 years of age to 99 at age 8 years and that these children continue to enjoy academic success at middle school age. 11 We therefore hypothesized that children born prematurely develop auxiliary or alternative systems for the neural processing of common language tasks.…”

mentioning

confidence: 99%

Cortical recruitment patterns in children born prematurely compared with control subjects during a passive listening functional magnetic resonance imaging task

Ment

Peterson

Vohr

et al. 2006

The Journal of Pediatrics

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Objectives-To use functional magnetic resonance imaging (fMRI) to test the hypothesis that subjects who were born prematurely develop alternative systems for processing language.Study design-Subjects who were born prematurely (n = 14; 600-1250 g birthweight) without neonatal brain injury and 10 matched term control subjects were examined with a fMRI passive listening task of language, the Clinical Evaluation of Language Fundamentals (CELF) and portions of the Comprehensive Test of Phonological Processing (CTOPP). The fMRI task was evaluated for both phonologic and semantic processing.Results-Although there were differences in CELF scores between the subjects born prematurely and control subjects, there were no significant differences in the CTOPP measures in the 2 groups. fMRI studies demonstrated that the groups differentially engaged neural systems known to process language. Children born at term were significantly more likely to activate systems for the semantic processing of language, whereas subjects born prematurely preferentially engaged regions that subserve phonology.Conclusions-At 12 years of age, children born prematurely and children born at term activate neural systems for the auditory processing of language differently. Subjects born prematurely engage different networks for phonologic processing; this strategy is associated with phonologic language scores that are similar to those of control subjects. These biologically based developmental strategies may provide the substrate for the improving language skills noted in children who are born prematurely.Magnetic resonance imaging (MRI) permits the investigation of structural aspects of the developing brain. 1,2 Volumetric, diffusion tensor imaging, and magnetic resonance spectroscopy studies suggest that preterm birth is associated with significant alterations in corticogenesis, and several investigators have suggested that those cortical regions that subserve language are particularly vulnerable to the injury associated with preterm birth. 3,4 In contrast, neural processing has been less well studied in subjects born prematurely, but may offer important insights into the functional aspects of brain development after preterm birth. 5Reprint requests: Laura R. Ment, MD, Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520; E-mail: laura.ment@yale.edu. Functional MRI (fMRI) is used extensively to study language processing in adults and children with known developmental disorders. 6,7 Preliminary studies of auditory tasks in children who were born prematurely suggest the presence of aberrant systems for language at school age, 5,8 yet recent neuropsychological studies document improvement in testing scores and school performance with time in children who were born prematurely. 9-12 NIH Public AccessWe previously reported in a study of almost 300 children born weighing 600 to 1250 g that the median Peabody Picture Vocabulary Test-Revised (PPVT-R) score, a standard measure for receptive vocabulary, incre...

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“…Another study of 22-to 25-year-olds found no differences between those with birth weight below 1000 g and controls in terms of employment, living independently, or marriage/cohabitation (Saigal et al, 2006).…”

Section: Adolescent and Adult Functioningmentioning

confidence: 94%

“…Limited data have been published on the functional abilities of adolescents and young adults born before term in the 1970s and early 1980s (Behrman and Butler, 2007;Grunau, Whitfield, and Fay, 2004;Hack et al, 2002Hack et al, , 2004Saigal et al, 2006). Although they were more likely than full-term controls to repeat one or more grades, to require special education, or to leave school early, 74% to 82% graduated from high school and 30% to 32% matriculated into colleges (but they were less likely than controls to enter 4-year colleges).…”

Section: Adolescent and Adult Functioningmentioning

confidence: 99%

Neurodevelopmental Consequences of Preterm Birth

Leppert¹,

Allen²

2009

Developmental-Behavioral Pediatrics

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Transition of Extremely Low-Birth-Weight Infants From Adolescence to Young Adulthood

Abstract: Our study results indicate that a significant majority of former ELBW infants have overcome their earlier difficulties to become functional young adults.

Cited by 209 publications

References 42 publications

Shyness and Timidity in Young Adults Who Were Born at Extremely Low Birth Weight

Shyness and Timidity in Young Adults Who Were Born at Extremely Low Birth Weight

Cortical recruitment patterns in children born prematurely compared with control subjects during a passive listening functional magnetic resonance imaging task

Neurodevelopmental Consequences of Preterm Birth

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