Transition metal ions induced secondary structural transformation in a hydrophobized short peptide amphiphile

Singh, Ramesh; Mishra, Narendra Kumar; Singh, Narendra; Gupta, Puneet; Joshi, Khashti Ballabh

doi:10.1039/d0nj01501f

Cited by 21 publications

(79 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, to understand the conformational variation between these two peptides, up to some extent, we wish to use the circular dichroism (CD) and Fourier‐transformed infrared (FT‐IR) spectroscopy. Both CD and FT‐IR are widely used spectroscopic techniques for analysis of conformation of peptides and proteins, in solution . Since, both the peptides showed completely different self‐assembled structures therefore initially circular dichroism (CD) spectroscopy was used to analyse the conformational differences between these two peptides up to some extent.…”

Section: Resultsmentioning

confidence: 99%

“…Though noncovalent interactions are primary stabilizing forces for self‐assembled structures but covalent crosslinking such as disulfide linkage and metal ion coordination with side chain also plays an important role in the formation, controlling and transformation of supramolecular nanostructures . Transition metal ions frequently utilized for conformational and morphological transformation due to their unique electronic structure and coordinating sites . Therefore, we were also interested to check the effect of metal introduction in peptide 1 and 2 .…”

Section: Resultsmentioning

confidence: 99%

“…The obtained peptide self‐assembling structures are stabilized by synergistic effect of attractive and repulsive intermolecular forces . The addition of metal ions rearranged these forces due to the binding with interacting sites and subsequently alter/break the sequence of noncovalent interactions in peptides but at the same time it provide linking between two electron donating sites through coordination.…”

Section: Resultsmentioning

confidence: 99%

“…It is due to high complexity of protein, peptides are simpler and therefore allowing easier manipulation and a higher degree of control for predictable assembly . Aromatic peptide, peptide amphiphiles, hairpin peptides to name a few, have frequently been used from the past decades. However, self‐assembly of designed short peptides conjugates also provides an excellent source of inspiration for engineering fascinating nanostructure of unusual shape and size …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Constitutionally Isomeric Aromatic Tripeptides: Self‐Assembly and Metal‐Ion‐Modulated Transformations

Singh

Joshi

et al. 2020

ChemPlusChem

Self Cite

View full text Add to dashboard Cite

Self-assembling peptides based on aromatic amino acids can adopt diverse nanostructures which primarily depend on their molecular structures. Therefore, to understand the nature of self-assembly on the molecular level we rationally designed two constitutional isomers of short aromatic peptides. The first isomer consists of a tyrosine moiety at the N-terminus and the second isomer consists of a tyrosine moiety at the C-terminus of the FF peptide, a core recognition motif of Amyloid β peptides. Therefore, it can be considered that both the designed tripeptides are the analogues of the FFF peptide with only atomic(À H) level replacement by À OH functional group on the first and last phenyl ring, respectively. The first isomer selfassembled into 2D porous nanosheets ("Nanowebs"), however the second isomers produced toroidal shapes with central spheres ("Nano-Saturn" like assemblies). Interestingly, the presence of the transition-metal ions (copper, zinc and iron) triggered the self-assembly of both the peptides into fibrous circular discs, nanomats and nanoplates like assembly.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Constitutionally Isomeric Aromatic Tripeptides: Self‐Assembly and Metal‐Ion‐Modulated Transformations

Singh

Joshi

et al. 2020

ChemPlusChem

Self Cite

View full text Add to dashboard Cite

show abstract

“…Lipid amphiphiles containing short peptides are also synthetic materials with many features that make them of interest to those working in the formation of fibrous and spherical nanostructures with metal nanoparticles and metal ions [25–28] . These unique nanostructures are able to form various assemblies based on intermolecular interactions due to their hydrophilic amino acids and hydrophobic alkyl chains.…”

Section: Introductionmentioning

confidence: 99%

Self‐assembly of Soluble Nanoarchitecture using Hybrids of Diblock Copolypeptide Amphiphiles with Copper Rubeanate Hydrates in Water and Their Electrooxidation Reaction

et al. 2020

View full text Add to dashboard Cite

A simple approach for producing supramolecular nanohybrids was developed allowing preparation of soluble hybrid two‐dimensional nanosheets in water through spontaneous organization of two‐dimensional Cu(II) rubeanate hydrate (which by itself does not dissolve in water or common organic solvents) and cationic diblock copolypeptide amphiphiles. These components self‐assembled into nanosheets with thicknesses of about several nm and widths on the order of several micrometers. Notably, the nanostructures were dependent on polypeptides containing leucine, suggesting that both cationic and hydrophobic polypeptide components are involved in generating the two‐dimensional (2D) nanosheet structures. The supramolecular hybrids exhibited excellent stability, and made it possible to control spectroscopic properties including ligand‐to‐metal‐charge‐transfer (LMCT), d‐d transition, electrochemical behavior, and electrooxidation reactions with ethanol in aqueous media.

show abstract

Covalent Grafting of Tanfloc on Titania Nanotube Arrays: An Approach to Mitigate Bacterial Adhesion and Improve the Antibacterial Efficacy of Titanium Implants

Singh,

Madruga,

Savargaonkar

et al. 2024

Adv Materials Inter

View full text Add to dashboard Cite

Implanted medical devices often face the challenge of infections, which can compromise their successful integration and use. To address this issue, this study demonstrates the covalent grafting of a tannin‐based antimicrobial biopolymer tanfloc (TAN) onto the titania nanotube arrays (TiNTs) surface to enhance antibacterial properties. Due to its polyphenolic and ionic structural configuration, tanfloc possesses unique properties that enable it to interact with and disrupt bacterial cell walls and membranes. Combining the topographical effect of TiNTs with the inherent antibacterial properties of tanfloc, this approach aims to mitigate bacterial threats on medical implants effectively. The successful attachment of tanfloc on TiNTs is confirmed through X‐ray photoelectron spectroscopy (XPS) and Fourier‐transform infrared spectroscopy (FT‐IR). The antibacterial and antibiofilm efficacy of the tanfloc‐functionalized TiNTs is evaluated against Staphylococcus aureus (Gram‐positive) and Pseudomonas aeruginosa (Gram‐negative) bacteria. The findings suggest that the covalent conjugation of tanfloc onto TiNTs is a promising approach to improve the infection resistance of titanium‐based medical implants, with potential applications in orthopedic, dental, and other biomedical device areas.

show abstract

Transition metal ions induced secondary structural transformation in a hydrophobized short peptide amphiphile

Abstract: Transition metal ions mediate the secondary structural transformation of hydrophobized sPA and can be applied to the design and development of stimuli-responsive nanomaterials.

Cited by 21 publications

References 55 publications

Constitutionally Isomeric Aromatic Tripeptides: Self‐Assembly and Metal‐Ion‐Modulated Transformations

Constitutionally Isomeric Aromatic Tripeptides: Self‐Assembly and Metal‐Ion‐Modulated Transformations

Self‐assembly of Soluble Nanoarchitecture using Hybrids of Diblock Copolypeptide Amphiphiles with Copper Rubeanate Hydrates in Water and Their Electrooxidation Reaction

Covalent Grafting of Tanfloc on Titania Nanotube Arrays: An Approach to Mitigate Bacterial Adhesion and Improve the Antibacterial Efficacy of Titanium Implants

Contact Info

Product

Resources

About