Transition metal ions and neurotransmitters: coordination chemistry and implications for neurodegeneration

Yoo, Jeasang; Han, J.; Lim, Mi Hee

doi:10.1039/d3cb00052d

Cited by 7 publications

(3 citation statements)

References 186 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The literature indicates that these pathological processes involve the contribution of metal ions [ 33 ]. Research has shown that transition metal ions, specifically Cu(I/II), Zn(II), and Fe(II/III), play a significant role in neuro-transmission [ 34 ]. This finding further emphasizes the importance of research in this area and highlights the potential for metal ions to be used as a therapeutic target in the development of drugs for neurodegenerative diseases.…”

Section: Resultsmentioning

confidence: 99%

Pleiotropic Potential of Evernia prunastri Extracts and Their Main Compounds Evernic Acid and Atranorin: In Vitro and In Silico Studies

Studzińska-Sroka,

Bulicz,

Henkel

et al. 2023

Molecules

View full text Add to dashboard Cite

Evernia prunastri is a lichen widely distributed in the Northern Hemisphere. Its biological properties still need to be discovered. Therefore, our paper focuses on studies of E. prunastri extracts, including its main metabolites evernic acid (EA) or atranorin (ATR). Phytochemical profiles using chromatographic analysis were confirmed. The antioxidant activity was evaluated using in vitro chemical tests and in vitro enzymatic cells-free tests, namely superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and catalase (CAT). The anti-inflammatory potential using cyclooxygenase-2 (COX-2) and hyaluronidase were determined. The neuroprotective potential using acetylcholinesterase, (AChE), butyrylcholinesterase (BChE), and tyrosinase (Tyr) was estimated. The hypoglycemic activity was also confirmed (α-glucosidase). Principal component analysis was performed to determine the relationship between the biological activity of extracts. The inhibitory effect of EA and ATR on COX-2 AChE, BChE, Tyr, and α-glucosidase was evaluated using molecular docking techniques and confirmed for EA and ATR (besides α-glucosidase). The penetration of EA and ATR from extracts through the blood–brain barrier was confirmed using the parallel artificial membrane permeability assay blood–brain barrier test. In conclusion, depending on chemical surroundings and the concentration, the E. prunastri extracts, EA or ATR, showed attractive pleiotropic properties, which should be further investigated.

show abstract

Section: Resultsmentioning

confidence: 99%

Pleiotropic Potential of Evernia prunastri Extracts and Their Main Compounds Evernic Acid and Atranorin: In Vitro and In Silico Studies

Studzińska-Sroka,

Bulicz,

Henkel

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…140–142 Such structural transformations could further lead to aggregation or polymerization, ultimately causing their loss of function. 143…”

Section: Copper-related Toxicity Mechanismsmentioning

confidence: 99%

Copper trafficking systems in cells: insights into coordination chemistry and toxicity

Han

2023

Dalton Trans.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Metal ions, M n + , play a fundamental role in neurochemistry. − While some alkaline and alkaline earth metal ions are essential for the proper regulation of neurotransmitter (NT) release and uptake, the interference of most other cations is detrimental and thought to trigger neurodegenerative diseases. Generally, this effect of metal ions on NTs is only indirect by binding to proteins gating NT transport.…”

Section: Introductionmentioning

confidence: 99%

Cation-Binding of Glutamate in Aqueous Solution

Friesen,

Kruchinin,

Fedotova

et al. 2024

J. Phys. Chem. B

View full text Add to dashboard Cite

Interactions of the cations Li + , Na + , Mg 2+ , and Ca 2+ with L-glutamate (Glu − ) in aqueous solution were studied at room temperature with dielectric relaxation spectroscopy in the gigahertz region. Spectra of ∼0.4 M NaGlu with added LiCl, NaCl, MgCl 2 , or CaCl 2 (c(MCl n ) ≤ 1.5 M) were evaluated and experiments supplemented by density functional theory and 3D reference interaction site model (3D-RISM) calculations. In addition to the modes found for aqueous NaGlu, namely, the reorientation of free Glu − ions (peaking at ∼1.6 GHz), of moderately retarded H 2 O molecules hydrating the carboxylate moieties of Glu − (∼8.4 GHz), of the cooperative resettling of the H-bond network of bulk water (∼20 GHz), and its preceding fast H-bond flip (∼400 GHz), an additional low-frequency relaxation at ∼0.4 GHz was detected upon the addition of the four salts. In the case of NaGlu + MgCl 2 (aq) and NaGlu + CaCl 2 (aq), this mode could be unequivocally assigned to an ion pair formed by the cation and the side-chain carboxylate moiety of Glu − . For NaGlu + LiCl(aq), either this species or a backbone-[Li + −H 2 O−Cl − −Glu − ] triple ion is formed. Binding constants increase in the order Li +

show abstract

Transition metal ions and neurotransmitters: coordination chemistry and implications for neurodegeneration

Abstract: Neurodegeneration is characterized by a disturbance in neurotransmitter-mediated signaling pathways. Recent studies have highlighted the significant role of transition metal ions, including Cu(I/II), Zn(II), and Fe(II/III), in neurotransmission, thereby making...

Cited by 7 publications

References 186 publications

Pleiotropic Potential of Evernia prunastri Extracts and Their Main Compounds Evernic Acid and Atranorin: In Vitro and In Silico Studies

Pleiotropic Potential of Evernia prunastri Extracts and Their Main Compounds Evernic Acid and Atranorin: In Vitro and In Silico Studies

Copper trafficking systems in cells: insights into coordination chemistry and toxicity

Cation-Binding of Glutamate in Aqueous Solution

Contact Info

Product

Resources

About