Transition Metal Ion FRET-Based Probe to Study Cu(II)-Mediated Amyloid-β Ligand Binding
Ri Wu,
Despoina Svingou,
Jonas B. Metternich
et al.
Abstract:Recent therapeutic strategies suggest that small peptides can act as aggregation inhibitors of monomeric amyloid-β (Αβ) by inducing structural rearrangements upon complexation. However, characterizing the binding events in such dynamic and transient noncovalent complexes, especially in the presence of natively occurring metal ions, remains a challenge. Here, we deploy a combined transition metal ion Forster resonance energy transfer (tmFRET) and native ion mobility-mass spectrometry (IM-MS) approach to charact… Show more
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