Transition-Metal-Free Diarylation of Isocyanates with Arynes

o-Silylaryl Triflates: A Journey of Kobayashi Aryne Precursors

“…Decarboxylation on intermediate 5-25 would occur to afford amine 5-26, which then undergoes the N-arylation reaction with a second aryne to give products 5-23. Similarly, Ko and co-workers developed both monoarylation 372 and diarylation reactions 373 on tosyl and aryl isocyanates (Scheme 57b). In these studies, they proposed that isocyanate hydrolysis takes place first to release primary amines before N-arylation.…”

Synthesis of Trinuclear Benzimidazole‐Fused Hybrid Scaffolds by Transition Metal‐Free Tandem C(sp2)−N Bond Formation under Microwave Irradiation

“…Among bases examined under the employed conditions, CsF was revealed to be the base of choice (Table 1, entry 14). [18] KO t Bu, NaO t Bu, and CsCl showed a similar activity as K 3 PO 4 with complete conversion of 1 a along with the formation of several unidentified products (Table 1, entries 9, 10, and 15). Other bases such as KOH, K 2 CO 3 , and Cs 2 CO 3 were not effective for the formation of 3 a (Table 1, entries 11-13).…”

N,N‐Diarylsulfonamide Reduces Proinflammatory Cytokine Interleukin‐6 Levels in Cells through Nuclear Factor‐κB Regulation

“…The author has cited the additional references within the supporting information. [30][31][32][33][34][35][36][37] After the incubation period, cells were harvested using RIPA lysis buffer and subjected to western blot analysis for specified antibodies (3A). Blots were quantified using ImageJ software and graphs were plotted (3B-3D).…”