Transition metal complexes of α-aminophosphonates part II: Synthesis, spectroscopic characterization, and in vitro anticancer activity of copper(II) complexes of α-aminophosphonates

Synthesis and potential antimicrobial activity of novel α-aminophosphonates derivatives bearing substituted quinoline or quinolone and thiazole moieties

“…Recently, α-aminophosphonates have received enormous attention from scientific researchers in pharmaceutical and medicinal chemistry [ 30 ], due to structural analogies to amino acids and exhibit many biological properties [ 31 ], such as anti-Alzheimer [ 32 ], antimicrobial [ 33 ], antiviral [ 34 ], and antioxidant [ 35 ]. The Kabachnik–Fields reaction is one and the simplest of the most practical approaches for α-aminophosphonate syntheses; the reaction generally requires various catalysts, such as CF 3 CO 2 H [ 36 ], TiO 2 [ 37 ], Amberlite-IR 120 [ 38 ], SnCl 2 [ 39 ], phenyl phosphonic acid [ 40 ], and ethyl lactate [ 41 ].…”

Synthesis, spectral and thermal studies of new Schiff base copper(II) complexes with their biological effect on Entomopathogenic nematodes

“…[24] Furthermore, the presence of various co-ligands with the Schiff base may influence the coordination geometry of the copper atom in the complexes, hence regulating the binding affinity with DNA/proteins. [25][26][27][28][29] The aim of the present study is, therefore, to prepare and characterize some Cu(II) Schiff base complexes of, (Z)-1,5-diphenyl-2-((thiophen-2-ylmethylene)amino)-1H-pyrrole-3carbonitrile (L 1 ) or (Z)-2-((2,4-dihydroxybenzylidene)amino)-1,5-diphenyl-1H-pyrrole-3carbonitrile (H2L 2 ) their biological effect on H.bacteriophora and S. carpocapsae nematodes was tested. This will include the determination of influence of these compounds on the mortality and rate of reproduction of nematodes.…”

Experimental and Molecular Docking Studies of Cyclic Diphenyl Phosphonates as DNA Gyrase Inhibitors for Fluoroquinolone-Resistant Pathogens

“…An important strategy in fighting antibiotic resistance is the discovery, development of novel antibiotics, and increasing the efficacy of the antibiotic that is already in a clinical study [ 7 ]. In this context, α-aminophosphonates gained great interest by medicinal chemists because of their diverse biological and industrial applications such as antibacterial [ 8 , 9 , 10 , 11 , 12 ], anticancer [ 13 , 14 , 15 ], enzyme inhibitors [ 16 , 17 ], and chelating material [ 18 , 19 , 20 , 21 ] which made them a promising drug candidate for further optimization. These compounds are phosphorus analogs of naturally occurring α-amino acids and therefore, are considered promising in the field of drug discovery and development [ 22 ].…”