Transition metal complexes as self-activating chemical nucleases: proficient DNA cleavage without any exogenous redox agents

Kumar, Pankaj; Tomar, Sunil; Kumar, Krishan; Kumar, Santosh

doi:10.1039/d3dt00368j

Cited by 6 publications

(1 citation statement)

References 136 publications

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“…On the one hand, the ability of synthetic molecules to catalyze DNA cleavage in physiological conditions has encouraged the search for novel therapeutic agents. Therefore, several copper complexes have been envisioned as potential anticancer agents by binding to/cleaving DNA [9][10][11][12][13][14][15][16][17][18]. Copper toxicity can also occur by a mechanism different from all other pathways of cell death, called cuproptosis [19,20].…”

Section: Introductionmentioning

confidence: 99%

Heteroleptic Copper(II) Complexes Containing an Anthraquinone and a Phenanthroline as Synthetic Nucleases and Potential Anticancer Agents

de Souza,

Silva,

Costa

et al. 2023

Inorganics

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Two ternary copper(II) complexes with an anthraquinone and a N,N-heterocyclic donor, [Cu(dmp)(L)(H2O)](ClO4) (1), [Cu(bpy)(L)(dmso)](ClO4) (2), in which dmp = 2,9-dimethyl-1,10-phenanthroline, bpy = 2,2′-bipyridine, and HL = 1-hydroxyanthracene-9,10-dione were synthesized and fully characterized by conductivity, elemental, and spectral analyses (FTIR and UV-Vis; EPR and ESI-MS). The structure of 1 reveals that Cu(II) is bound to two oxygens of L, two nitrogens of dmp, and a molecule of water in the fifth position. In complex 2.1, Cu(II) is also pentacoordinated with an O-bonded dmso in the axial position. The presence of the heteroleptic complexes in solution was evidenced by ESI-MS, EPR in dmso solution and UV-Vis spectrophotometry. All complexes bind to CT-DNA with affinity constants of approximately 104. Complex 2 can nick plasmid DNA but no cleavage was performed by complex 1. The investigation of DNA interactions by spectrofluorimetry using ethidium bromide (EB) showed that it was displaced from DNA sites by the addition of the complexes. The complexes inhibited the growth of chronic myelogenous leukemia and human squamous carcinoma cells with low IC50 values, complex 1 being the most effective.

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Section: Introductionmentioning

confidence: 99%

Heteroleptic Copper(II) Complexes Containing an Anthraquinone and a Phenanthroline as Synthetic Nucleases and Potential Anticancer Agents

de Souza,

Silva,

Costa

et al. 2023

Inorganics

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Highly Fluorescent π-Conjugated Azomethines and Divalent Metal Complexes as Antibacterial and Antibiofilm Nominees

Baydeniz,

Uçan,

Sevgi

et al. 2024

J Fluoresc

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Abstractπ-Conjugated azomethine ligands differing in the naphthalene or phenylmethane-centered core structure and their divalent cobalt, nickel, copper, and zinc metal complexes were prepared and well-characterized by spectral analyses in solid state. Magnetic natures of the complexes were determined by magnetic susceptibility measurements in solid-state. Their remarkable photophysical characteristics were recorded by Uv–vis and Fluorescence spectroscopic techniques. At their excitation wavelenght of 265 nm, all molecules exhibited triple fluorescence emission bands with promising intensities above 673 nm in near infra-red region. Antibacterial and antibiofilm activities of the π-conjugated azomethines are promising for potential applications in medical and healthcare settings. Hence, the antibacterial/antibiofilm activity of the π-conjugated azomethine ligands and their metal complexes against some clinically important bacteria namely Staphylococcus aureus (MSSA), Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa and Proteus mirabilis was investigated, and the obtained results have shown that the ligands and complexes had a remarkable antibacterial effect, especially on Proteus mirabilis. Metal complexes have been found to have a significant inhibitory effect on biofilm formation by MRSA, MSSA, and P. mirabilis compared to ligands. The copper (II) complex of ligand-2 showed the highest inhibition percentage, significantly reducing biofilm formation for MRSA and MSSA. Furthermore, cobalt (II) complexes of the ligands selectively inhibited the growth of the opportunistic pathogen P. mirabilis biofilms, indicating that metal complexes might be a good choice for future antibiofilm studies.

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DNA and albumin interaction studies of imidazole-based thiosemicarbazone-metal(II) chelates using spectroscopic and molecular docking methods: DNA cleavage, antioxidant and anti-inflammatory properties

Kathiresan,

Kesavan,

Annaraj

et al. 2023

Inorganic Chemistry Communications

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Transition metal complexes as self-activating chemical nucleases: proficient DNA cleavage without any exogenous redox agents

Abstract: Chemical nucleases have found potential applications in the research fields of chemistry, biotechnology and medicines. A variety of metal complexes have been explored as good to outstanding therapeutic agents for...

Cited by 6 publications

References 136 publications

Heteroleptic Copper(II) Complexes Containing an Anthraquinone and a Phenanthroline as Synthetic Nucleases and Potential Anticancer Agents

Heteroleptic Copper(II) Complexes Containing an Anthraquinone and a Phenanthroline as Synthetic Nucleases and Potential Anticancer Agents

Highly Fluorescent π-Conjugated Azomethines and Divalent Metal Complexes as Antibacterial and Antibiofilm Nominees

DNA and albumin interaction studies of imidazole-based thiosemicarbazone-metal(II) chelates using spectroscopic and molecular docking methods: DNA cleavage, antioxidant and anti-inflammatory properties

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