Transition metal complex assisted C_sp3–F bond formation

Abstract

Fluoroorganic compounds have attracted significant attention in various fields, such as pharmaceutical, agricultural chemistry, and materials science, as a result of their unique physical, chemical, and physiological properties. Consequently, extensive efforts have been devoted to the site-specific synthesis of organofluorine compounds. In recent years, transition-metal-mediated C-F bond formation has emerged as a powerful method for fabrication of these compounds. this Perspective mainly focuses on the most recent advances in transition-metal-assisted synthesis of alkyl fluorides.

The Versatile Behavior of Platinum Alkyne Complexes towards XeF2: Formation of Fluorovinyl and Fluorido Complexes

“…[11][12][13][14][15][16][17][18][19] One approach to access fluorinated buildingb locks involves metal-mediated fluorination reactions, which can often be regarded as efficient alternatives to conventional fluorination methods. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] The CÀFb ond formation generally takes place either by electrophilic or nucleophilic fluorinationo ft he ligand or the metal. For the latter,m etal fluorido species can be intermediates, which then, for instance, undergo CÀFr eductive elimination.…”

Reactivity of platinum alkyne complexes towards N-fluorobenzenesulfonimide: formation of platinum compounds bearing a β-fluorovinyl ligand

“…[9][10][11][12][13][14][15] A prerequisite for the synthesis of fluorinated entities can be the selective formation of the C-F bond, which is often a challenging synthetic step. [36][37][38][39][40][41][42][43][44][45][46] One interesting topic concerns the fluorination of unsaturated carbon-carbon bonds. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Mechanistic studies distinguish between the formation of a transition metal fluorido complex followed by intramolecular fluorination and the intermolecular fluorination of the metal bound ligand by an external fluoride source.…”

Aryl-BIAN-ligated silver(i) trifluoromethoxide complex

“…34 It is well recognized that fluorinated organometallic reagents provide a useful and convenient route for the incorporation of fluorinated functionality into organic molecules. [35][36][37][38][39] Vicic and co-workers have reported the synthesis and structures of Cu(I) and Au(I) trifluoromethoxide complexes with N-heterocyclic carbene ligands. 40 However, none of these complexes has been examined for the reactivity towards trifluoromethoxylation.…”