Transition-Metal-Catalyzed Regio- and Diastereoselective 1,4-Conjugate Addition­ of Zerumbone Using Boronic Acids: A Simple Route toward Novel Zerumbone Derivatives

Abstract

A straightforward method for the synthesis of novel derivatives of zerumbone via palladium-and rhodium-catalyzed regio-and diastereoselective 1,4-conjugate addition using boronic acids is developed. The reaction is general for aryl boronic acids containing both electron-donating and electron-withdrawing groups.