Transition-Metal-Catalyzed Oxidative Cross-Coupling Reactions

Abstract

The oxidative coupling between two nucleophiles using desyl chloride (2-chloro-1,2-diphenylethanone) or molecular oxygen as the oxidant, which just acts as the electron acceptor, is discussed. Various metal reagents were employed as good partners in the oxidative couplings.

Silver nitrate promoted synthesis of tetraphenyl derivatives and diaryl ketones

“…Column chromatography was performed using the MACHEREY-NAGEL silica gel 60 mit with a mixture of ethyl acetate/hexane or hexane as an eluent. 1 H NMR spectra were recorded on 400 MHz & 600 MHz, 13 C-NMR spectra were recorded on 100 MHz & 151 MHz, and Varian Mercury spectrometer using CDCl3 as solvent. The spectra were recorded and presented as chemical shifts (ppm).…”

“…The di-benzyl core structure is a highly versatile scaffold, offering the potential for the synthesis of a range of compounds in natural products and pharmaceuticals. [1][2][3][4] The most conventional method for obtaining di-benzyl derivatives is reducing carbon-carbon multiple bonds. 5,6 The oxidative homo coupling reaction imposes valuable tools, and the use of oxidizing reagents triggered the transformation of toluene derivatives into dibenzylic compounds.…”

Pd-Catalyzed Oxidative Functionalization of Alkenes, Arenes, and 1,3-Dienes Using Molecular Oxygen as the Terminal Oxidant

“…Coupling reactions can be classified into three types: (I) coupling reactions with electrophiles and nucleophiles, (II) oxidative couplings with nucleophiles, and (III) reductive couplings with electrophiles. 1,2 Oxidative couplings involve cleavage of ubiquitous bonds such as C-H and heteroatom-H bonds in substrates. 3 This characteristic feature realizes more atom-and step-economical transformations than the other coupling reactions.…”