Transition-Metal Catalyzed Modification of Nucleosides

Pd/PTABS: An Efficient Catalytic System for the Aminocarbonylation of a Sugar-Protected Nucleoside

“…A series of catalytic reactions with different bases, namely Et 3 N, DIPEA and DBU (organic soluble bases), as well as some inorganic bases, viz. K 2 CO 3 and Cs 2 CO 3 were carried out (entries [19][20][21][22]. In spite of the wide range of bases analyzed, Et 3 N provided the optimum result in terms of yield.…”

“…In past decades, significant progress has been made on nucleoside chemistry, 21 ranging from their synthesis, modification and photophysical examination, leading to their potential exploration in the field of medicines. 22 For the construction of such macromolecular biologically relevant motifs/devices and for the installation of important functionalities such as amides (as seen in Figure 1), the role of smaller building blocks (such as carbon monoxide) is crucial and significant 23 as they offer elegant synthetic pathways for molecules 24 of high commercial and biological relevance. 25,26 The amide functionality in nucleoside chemistry has proved useful due to the restricted rotation of the amide bond 27,28 and its ability to serve as both a hydrogen bond acceptor and donor, 29 thus providing an attractive prospect for the assessment of new H-bonding contacts with different protein targets and eventually helping in DNA stabilization.…”

Transition metal oxide (NiO, CuO, ZnO)-doped calcium oxide catalysts derived from eggshells for the transesterification of refined waste cooking oil

“…The main purpose of developing these mixed metal oxide catalysts was to enhance their physicochemical properties in terms of the stability, catalytic activity and basic strength of the catalysts. According to Gayakhe et al , 16 transition metal oxides (such as NiO, CuO and ZnO) tend to become a co-catalyst because of their characteristics, including variable oxidation state, ion complex formation and high catalytic efficiency. To our best knowledge, the synthesis of the new mixed metal oxides by incorporation of transition metal oxides (NiO, CuO and ZnO) into calcium oxide-based catalysts derived from waste eggshells in the transesterification of refined waste cooking oil has not been explored.…”

Tandem Homometallic or Multimetallic Catalysis for Assembly of Base‐Modified Nucleosides

“…Nucleoside modification for the development of fluorescent molecules as well as potential drug candidates is the need of the hour for rapid viral DNA detection and treatment (Goncalves, 2017). Transition metal−catalyzed processes have certainly come to the fore in the past several years to provide access to such diverse nucleoside molecules (Gayakhe et al., 2018). However, despite the progress made in metal‐mediated processes, the possibility of synthesizing such structurally diverse molecules via a multi‐step process is not a synthetically viable and sustainable option.…”