Transition-Metal-Catalyzed Cross-Coupling Reactions of Grignard Reagents

Abstract

Transition-metal-catalyzed cross-coupling of organo­halides, ethers, sulfides, amines, and alcohols (and derivatives thereof) with Grignard reagents, known as the Kumada–Tamao–Corriu reaction, can be used to prepare important intermediates in the synthesis of numerous­ biologically active compounds. The most frequently used transition metals are nickel, palladium, and iron, but there are several examples for cross-coupling reactions catalyzed by copper, cobalt, manganese, chromium, etc. salts and complexes. The aim of this review is to summarize the most important transition-metal-catalyzed cross-coupling reactions realized in the period 2000 to 2020.1 Introduction2 Nickel Catalysis3 Palladium Catalysis4 Iron Catalysis5 Catalysis by Other Transition Metals5.1 Cobalt Catalysis5.2 Copper Catalysis5.3 Manganese Catalysis5.4 Chromium Catalysis6 Conclusion

Pd@l-asparagine–EDTA–chitosan: a highly effective and reusable bio-based and biodegradable catalyst for the Heck cross-coupling reaction under mild conditions

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Supramolecular Pd@methioine-EDTA-chitosan nanocomposite: an effective and recyclable bio-based and eco-friendly catalyst for the green Heck cross-coupling reaction under mild conditions

“…Indeed, this reaction has been emerged as an efficient replacement, working under mild conditions, for the Grignard reagents as well as other organic transformations to construct C]C bonds. [12][13][14][15] One of the extensive applications of the HCR is in the synthesis of cinnamic acid derivatives (CADs). Cinnamic acid (CA) is a natural aromatic carboxylic acid, which is found in plants and honey.…”

Aggregation Enabled Alkene Insertion into Carbon--Halogen Bonds

“…Owing to the diverse and rich reaction chemistry associated with carbon-halogen (C-X) bonds, organohalides are crucial in synthetic chemistry. [11][12][13][14][15] Moreover, they are prevalent structural subunits in numerous important natural products and pharmaceuticals. [16][17][18][19] Although halides can be obtained by numerous methods, efficient, practical, and green methods are currently being developed.…”