Transition-metal-catalyzed C–H bond activation/functionalization and annulation of phthalazinones

Abstract

Phthalazinones and their higher congeners are commonly prevalent structural motifs that occur in natural products, bioactive molecules, and pharmaceuticals. In the past few decades transition metal-catalyzed reactions have received an...

Catalyst-Free Green Synthesis of Phthalazinones at Room Temperature

“…[9][10][11][12][13] Among the numerous nitrogen-containing heterocycles, phthalazinone is a kind of annulated six-membered N-heterocycles and has diverse biological activities. [14][15][16][17][18] Phthalazinone and their derivatives have been widely used in the treatment of a variety of diseases such as diabetes, hepatitis B, asthma, vascular hypertension, arrhythmia, cancers, and are as potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) (Figure 1). [19][20][21][22][23] For example, azelastine, a phthalazinone derivative, is a well-known antiallergic and antiasthmatic drug (sales $0.24 billion in 2008).…”

Ethanol Oxidation Reaction Mechanism on Gold Nanowires from Density Functional Theory

“…We chose ethanol with the intention of also exploring the activation of the CÀ H bond in the À CH 2 À group. The activation of the CÀ H bond is well established in the literature and is defined as the β-CÀ H mechanism [23][24][25][26] and in this work we explore the mechanism of breaking the CÀ H bond of ethanol.…”

Rhodium(iii)-catalyzed C–H alkylation of arylhydrophthalazinediones with α-Cl ketones as sp3-carbon alkylated agents

“…10 By embracing this area, transition-metal-cata-lyzed C-H activation, especially in alkylation of 2-arylphthalazine-1,4-diones with different coupling partners, has attracted great interest in recent years. 11 In 2019 and 2022, the two groups of Sakhuja 12 and Yu 13 demonstrated Ru(II)-catalyzed C-H alkylation from 2-arylphthalazine-1,4-diones and sulfoxonium ylides, respectively (Scheme 1a). In 2020, Kim and coworkers 14 reported a Ru(II)-catalyzed C-H alkylation of 2-arylphthalazine-1,4-diones with a range of aldehydes and activated ketones (Scheme 1b).…”