Transition metal and radical free 1,2-dicarbofunctionalisation of 1,1-arylboryl alkenes through dual C(sp3)-C(sp3) bond formation

Abstract

We reveal here the regioselective nucleophilic addition of C(sp3) to 1,1-arylboryl alkenes, followed by nucleophilic attack of the alpha-boryl carbanionic intermediates to C(sp3) electrophiles, at room temperature. We envisioned this goal through engaged C(sp3) chemical entities avoiding metal catalysts, additives, radical initiators or specific irradiation. This multicomponent reaction guarantees that the new tetrasubstituted carbon formed retains all the C atoms from the three starting materials involved in the assembly.