Transition from meningeal melanocytoma to primary cerebral melanoma

Röser, Florian; Nakamura, Makoto; Brandis, Almuth; Hans, Volkmar; Vorkapic, Peter; Samii, Madjid

doi:10.3171/jns.2004.101.3.0528

Cited by 68 publications

(63 citation statements)

References 19 publications

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“…Meningeal melanocytoma is a rare tumor and was first described by Limas and Tio in 1972 (2). Its biological behaviour is not always clearly benign: recurrence, invasion, progression and liquor seeding are reported (3,4,5). The appearance of two or multiple lesions as in our case is considered very rare (6).…”

Section: Discussionmentioning

confidence: 93%

Neurocutaneous Melanosis in a Woman with Multiple Brain Melanocytomas, Cutaneous Melanocytosis and Oral Involvement

et al. 2013

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A 34-year-old female was referred to us for a consultation of her dermatological lesions (pigmented lesions present in her oral cavity and on her right shoulder) in May 2007. These lesions had been present since childhood. Recently, the patient had developed seizures and a headache. An MRI of the brain showed the presence of two intracranial masses. The intracranial tumours were surgically removed whereas skin and mucosal lesions were biopsied. Histological findings of brain tumours were consistent with a diagnosis of "melanocytoma" while cutaneous lesions presented "benign dermal melanocytic infiltrations". Whole brain irradiation was performed. After 3 months a new melanocytic skin lesion appeared on the scalp with histological picture similar to the other cutaneous ones. At the 5-year follow-up examination no recurrence of intracranial tumour or other skin or mucosal lesions were registered. According to the clinical and histological findings, we classify our case as a form of neurocutaneous melanosis in a young adult patient and we present it for the rarity of this syndrome, for the difficulty of the diagnosis, for the potential aggressive behaviour of intracranial lesions that necessitates a constant attentive follow-up and for the unusual feature of new developing skin lesion during the course of the disease.

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Section: Discussionmentioning

confidence: 93%

Neurocutaneous Melanosis in a Woman with Multiple Brain Melanocytomas, Cutaneous Melanocytosis and Oral Involvement

et al. 2013

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“…Immunohistochemistry shows a positive reaction for HMB-45 and S-100 protein. 10,12) Immunoperoxidase staining for GFAP, NSE, epithelial membrane antigen, and cytokeratin is usually negative. 10) In our case, S-100 protein was positive but HMB-45 was negative.…”

Section: Discussionmentioning

confidence: 99%

“…10,12) Immunoperoxidase staining for GFAP, NSE, epithelial membrane antigen, and cytokeratin is usually negative. 10) In our case, S-100 protein was positive but HMB-45 was negative. S-100 protein is present in the tumor cell nucleus of melanomas, with a sensitivity of 97-100%.…”

Section: Discussionmentioning

confidence: 99%

“…Ultrastructurally, dendritic cytoplasmic processes are found, with many melanosomes and/or premelanosomes at various stages of maturity without desmosomes and interdigitating cytoplasmic processes. 10) Complete tumor resection is considered the best treatment option, followed by incomplete resection with postoperative radiotherapy. 9) The efficacy of radiotherapy remains to be established, but is often delivered to treat residual or recurrent lesions.…”

Section: Discussionmentioning

confidence: 99%

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Meningeal Melanocytoma Extruded From the Skull of a Neonate -Case Report-

Nakahara

Morota

Ihara

et al. 2010

Neurol. Med. Chir.(Tokyo)

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Ultrasonography performed at 21 weeks of gestation and magnetic resonance imaging at 23 weeks identified a huge tumor in the occipital region. Premature rupture of the membrane occurred at 28 weeks of gestation, so this baby boy was delivered by emergency cesarean section. Anemia and low blood pressure due to hemorrhage from the surface of the tumor required massive blood transfusion and hemostasis. The tumor was conservatively managed. He manifested symptoms of high output heart failure and persistent infection, necrotizing enterocolitis, and septicemia, and died 51 days after birth. Autopsy examination found the black tumor, weighing 885 g, with a clear boundary with the brain parenchyma. Histological examination showed the tumor was contiguous with the thickened dura mater. The tumor consisted of small, spindle-shaped, round, and polygonal cells without characteristic organized pattern, and positive for S-100 protein and neuron-specific enolase, and negative for HMB-45 and glial fibrillary acidic protein. Ultrastructural study revealed melanin granules within the tumor cells. The diagnosis was meningeal melanocytoma. His skin and spinal cord were unremarkable. Complete tumor resection is considered the best treatment option, followed by incomplete resection with postoperative radiotherapy, but we could not deliver aggressive treatment in our patient because of hemorrhage from the tumor surface and his poor general condition.

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“…Resection of the frontal tumor diagnosed a primary malignant meningeal melanoma with cerebrospinal fluid dissemination once the patient has no melanocytic lesions outside the CNS. The melanocytic lesions ranges from melanocytoma to melanoma 2,3,4,5 . Malignant melanoma should be included in the differential diagnosis of neoplastic CSF dissemination with bilateral IAC lesions mimicking schwannomas in NF2.…”

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confidence: 99%