Transition between columnar absorptive cells and goblet cells in the rat jejunal epithelium.

Kurosumi, Kazumasa; Shibuichi, Izumi; Tosaka, Hisami

doi:10.1679/aohc1950.44.405

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…Small apical granules in the intestinal crypt cell were noted by TROUGHTON and TRIER (1969) and KATAOKA (1970) In the mouse, by MOXEY and TRIER (1978) in the human fetus and by KURosuMI et al (1981) in the rat. Two contradictory views were proposed as to nature of these granules; KATAOKA (1970) regarded them as secretory granules, while KuRosuMI et al (1981) suggested an absorptive function.…”

Section: Fine Structural Changes In Proliferative Cellsmentioning

confidence: 97%

“…Two contradictory views were proposed as to nature of these granules; KATAOKA (1970) regarded them as secretory granules, while KuRosuMI et al (1981) suggested an absorptive function.…”

Section: Fine Structural Changes In Proliferative Cellsmentioning

confidence: 99%

“…In fact, their content shows various electron densities-electron lucent, moderately dense and dense -and the granules in the Golgi area are usually moderately dense . It cannot be denied that some of the apical granules are related to the absorptive function of the crypt cell as suggested by KUROSUMI et al (1981). The other possibility is that they may, at least partly, belong to surface-forming vesicles which supply the plasmalemmal component and glycocalyx for the formation of microvilli (BoNNEVILLE and WEINSTOcK, 1970).…”

Section: Fine Structural Changes In Proliferative Cellsmentioning

confidence: 99%

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Histogenesis of the mouse jejunal mucosa, with special reference to proliferative cells and absorptive cells.

Hirano

Kataoka

1986

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Fine Structural Changes In Proliferative Cellsmentioning

confidence: 97%

“…Two contradictory views were proposed as to nature of these granules; KATAOKA (1970) regarded them as secretory granules, while KuRosuMI et al (1981) suggested an absorptive function.…”

Section: Fine Structural Changes In Proliferative Cellsmentioning

confidence: 99%

Section: Fine Structural Changes In Proliferative Cellsmentioning

confidence: 99%

See 1 more Smart Citation

Histogenesis of the mouse jejunal mucosa, with special reference to proliferative cells and absorptive cells.

Hirano

Kataoka

1986

Arch. Histol. Jap., Arch. Histol. Jpn

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Goblet cells and intestinal Alkaline phosphatase expression (IAP) during the development of the rat small intestine

et al. 2017

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Gastric digestion of protein through pancreozyme action optimizes intestinal forms for absorption, mucin formation and villus integrity

Moran

2016

Animal Feed Science and Technology

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a b s t r a c tRecovery of dietary protein proceeds through two phases of digestion before suitable forms exist for absorption. The first phase engages the gastric system where low pH weakens overall structures allowing pepsin to disrupt hydrophobic bonding and enhance aqueous compatibility. Secondly, trypsin, chymotrypsin and elastase proteolysis in conjunction with carboxypeptidases A and B cooperate to form a mixture of free amino acids and peptides that progressively arise in the small intestinal lumen. Free amino acids are dominated by the aromatic, aliphatic and basic ones while resulting peptides largely involve the nonessentials.Motility convectively transfers digestion products to the unstirred water layer of the upper villus where filtration limits entry to low molecular weight solutes that can be further digested by underlying enzymes to optimize membrane absorption. Mucin oligosaccharides are credited for creating a microenvironment having reduced pH's ∼5.5-6.0 that favors enzymes finalizing digestion as well as absorption of two type peptides. This pH is speculated to optimize peptide forms having either a zwitterion-like charge for proton gradient transfer or be non-dissociated and passively diffused. A high frequency of peptides having either glycine or proline can be rationalized as providing particularly favorable electronic terms for peptide absorption by either approach while being non-competitive.The upper villus has first access to absorbed products where goblet cells assure continuance of mucin and continuity of the unstirred water layer. Glutamine is their dominant nutrient for synthesis of mucin oligosaccharides while also providing glutamic acid for either formation of its associated protein or is consumed for energy. Dietary cystine and threonine are frequently limiting, and their assurance is necessary for the mucin core while ready availability of glycine and/or serine together with proline also foster mucin formation. Unused absorbed products descend the villus in venules adjacent to the surface and provide nutrition as well as information about the lumen for adaptation of replacement cells. Sustaining the villus with absorbed nutrients takes priority for continuation of operational efficiency before their entry into the portal system and subsequent body use.

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Transition between columnar absorptive cells and goblet cells in the rat jejunal epithelium.

Cited by 6 publications

References 25 publications

Histogenesis of the mouse jejunal mucosa, with special reference to proliferative cells and absorptive cells.

Histogenesis of the mouse jejunal mucosa, with special reference to proliferative cells and absorptive cells.

Goblet cells and intestinal Alkaline phosphatase expression (IAP) during the development of the rat small intestine

Gastric digestion of protein through pancreozyme action optimizes intestinal forms for absorption, mucin formation and villus integrity

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