Transition and remission in adolescents at ultra-high risk for psychosis

Ziermans, Tim; Schothorst, Patricia F.; Sprong, M.; Engeland, Hermán van

doi:10.1016/j.schres.2010.10.022

Cited by 137 publications

(131 citation statements)

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“…121 Three prodromal risk syndromes have been described in these instruments, characterized by Prospective studies have demonstrated that approximately 15% to 40% of young people who present to the clinic with these putative prodromal risk syndromes go on to develop a psychotic disorder within the proceeding 2 years. [122][123][124][125][126] As a result, these individuals are considered an ultra-high-risk (UHR) group for psychosis. 127 …”

Section: Predicting Risk and The Emergence Of Schizophreniamentioning

confidence: 99%

Predicting Risk and the Emergence of Schizophrenia

Clarke

Kelleher

Clancy

et al. 2012

Psychiatric Clinics of North America

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Section: Predicting Risk and The Emergence Of Schizophreniamentioning

confidence: 99%

Predicting Risk and the Emergence of Schizophrenia

Clarke

Kelleher

Clancy

et al. 2012

Psychiatric Clinics of North America

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“…Only a handful of studies have looked at the presentation of at-risk adolescents [35][36][37][38] excluding studies where risk is solely based on genetic predisposition. In one of the first studies, Meyer and colleagues [36] identified 24 adolescents who reported significant perceptual abnormalities (20/24, 83%), unusual thought content (18/24, 75%) and suspiciousness (13/54%) symptoms at baseline assessment.…”

Section: Introductionmentioning

confidence: 99%

“…In one of the largest studies to date Ziermans and colleagues [38] assessed 72 adolescents and discovered that the vast majority presented with impaired functioning (Mean GAF= 59.6), some form of attenuated psychotic symptoms (90.3%), but few reported a history of regular cannabis abuse (around 20%).…”

Section: Introductionmentioning

confidence: 99%

The ‘At-Risk Mental State’ for Psychosis in Adolescents: Clinical Presentation, Transition and Remission

Welsh

Tiffin

2013

Child Psychiatry Hum Dev

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. (2014) 'The 'At-risk mental state' for psychosis in adolescents : clinical presentation, transition and remission.', Child psychiatry and human development., 45 (1). pp. 90-98.Further information on publisher's website:http://dx.doi.org/10.1007/s10578-013-0380-z Publisher's copyright statement:The nal publication is available at Springer via http://dx.doi.org/10.1007/s10578-013-0380-z.Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. 2 Abstract:Despite increased efforts over the last decade to prospectively identify individuals at ultrahigh risk of developing a psychotic illness, limited attention has been specifically directed towards adolescent populations (<18 years). In order to evaluate how those under 18 fulfilling the operationalised criteria for an At-Risk Mental State (ARMS) present and fare over time, we conducted an observational study. Participants (N=30) generally reported a high degree of functional disability and frequent and distressing perceptual disturbance, mainly in the form of auditory hallucinations. Seventy percent (21/30) were found to fulfil the criteria for a co-morbid ICD-10 listed mental health disorder, with mood (affective; 13/30) disorders being most prevalent. Overall transition rates to psychosis were low at 24 month follow-up (2/28; 7.1%) whilst many participants demonstrated a significant reduction in psychotic-like symptoms. The generalisation of these findings may be limited due to the small sample size and require replication in a larger sample.

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“…Cornblatt [16] (48, 12-to 18-year-old, adolescents with attenuated psychotic symptoms) reported that at-risk adolescents converted to psychosis later than expected from studies of adults. However, Ziermans [17] (58, 12-to 18-year-old, adolescents with UHR criteria or COGDIS) reported that the conversion rate was slightly lower but not delayed compared to adults (16 % in 2 years). Data on children below age 12 are not available.…”

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confidence: 96%

“…Notably, it was assumed for a long time that an adolescent onset of psychosis (before age 18, EOP) is associated with worse outcomes compared to adult-onset psychosis (AOP; [5]). However, two recent studies comparing EOP (age [14][15][16][17] with AOP (age 18-30) did not support this assumption. They indicated that EOP when also treated in an early psychosis, prevention and intervention centre have similar short-term [6] and similar or even better long-term outcomes [7].…”

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confidence: 99%