Transintestinal cholesterol efflux

Velde, Astrid E van der; Brufau, Gemma; Groen, Albert K.

doi:10.1097/mol.0b013e3283395e45

Cited by 119 publications

(77 citation statements)

References 49 publications

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“…This route may involve stimulation of intestinal, nonbile-derived cholesterol excretion, and is called trans-intestinal cholesterol excretion (TICE) (20). TICE likely occurs via an active system present in the proximal part of the small intestine and involves transport of the cholesterol present in the basolateral and apical sides of the enterocytes back into the intestinal lumen (20).…”

Section: Absorption Of Cholesterol and Phytosterolsmentioning

confidence: 99%

Do clinical and experimental investigations support an antiatherogenic role for dietary phytosterols/stanols?

et al. 2012

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SummaryThe plasma cholesterol-reducing effect of phytosterols (PS) has been recognized in several studies, but the usefulness of PS in preventing coronary heart disease remains controversial, as some investigations claim that the high PS concentrations found in plasma and specific tissues are related to an increased risk of cardiovascular events. It has also been demonstrated that PS may induce inflammation and reduce cholesterol efflux from macrophages, conditions that are directly implicated in the development of atherosclerosis. As to arterial dysfunction and atherosclerosis, some studies have concluded that plasma PS concentrations are unrelated or only weakly related or that PS intake or plasma PS concentrations are harmful. Thus, in light of the National Cholesterol Education Program-ATPIII report, it is necessary to evaluate the relevance of their findings. To this end, we have evaluated the studies conducted on cells, animal models, and humans regarding the influence of PS on the development of atherosclerosis.2012 IUBMB IUBMB Life, 64(4): [296][297][298][299][300][301][302][303][304][305][306] 2012

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Section: Absorption Of Cholesterol and Phytosterolsmentioning

confidence: 99%

Do clinical and experimental investigations support an antiatherogenic role for dietary phytosterols/stanols?

et al. 2012

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“…Expression of these genes is regulated by the peroxisome proliferator-activated receptors (PPARs) [23] and the nuclear liver X receptors (LXRs) [24]. Furthermore, direct secretion of cholesterol from the blood compartment into the intestine, also known as transintestinal cholesterol excretion (TICE), plays a major role in disposal of cholesterol via the feces, at least in mice [25]. An increase in intestinal absorption of cholesterol occurs in diseases such as diabetes mellitus leading to high plasma cholesterol and increased risk of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Intestinal Cholesterol Absorption: A Disease Perspective

Iqbal¹,

Qarni²,

Hawwari³

2017

ABC

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Hypercholesterolemia promotes atherosclerosis and precise regulation of cholesterol homeostasis is essential. Besides risk factor for cardiovascular disease, abnormalities in cholesterol metabolism have been associated with type 2 diabetes. Cholesterol homeostasis in the body is maintained by de novo synthesis. Furthermore, intestinal cholesterol absorption has recently been considered as an important control point in cholesterol homeostasis. Important insights have been gained into the mechanisms of transport of cholesterol from the intestinal lumen into the enterocytes. Several transporter proteins that appear to be key players in the control of the cholesterol absorption from the intestinal lumen have been identified. Here, we review intestinal cholesterol absorption and the mechanisms underlying alterations in cholesterol absorption under physiological conditions and in diseases such as diabetes mellitus.

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“…Cholesterol is synthesis in hepatocytes through mevalonate pathway with the help of HMG CoA Reductase (HMGR) (Petras et al, 1999) and secreted into bloodstream as a forward pathway in order to supply cholesterol to peripheral cells (Friedman et al, 2009). Conversely, reverse cholesterol transport (RCT), the process by which excess cholesterol is effluxed from cells into high density lipoprotein (HDL) particles, helps to carry out excess cholesterol and returned to the liver for excretion from the body (Ghosh, 2010;van der Velde et al, 2010). This process is crucial in regulating cholesterol homeostasis by facilitating the prevention of lipid accumulation, particularly, in atherosclerotic lesions and therefore, RCT is considered an atheroprotective process.…”

Section: Introductionmentioning

confidence: 99%

“…Stimulation of reverse transport of cholesterol from cells of the arterial wall to the liver is considered the mechanism by which HDL exerts its anti-atherogenic properties. In addition, interaction of HDL with the arterial wall directly protects against oxidative stress and vascular inflammation (van der Velde et al, 2010). Therefore, low level of HDL is considered as an important risk factor for the development of atherosclerosis (Ghosh, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of Tinospora crispa aqueous extract in regulating cholesterol metabolism in human hepatoma cancer cell line (Hep G2)

Shah¹,

Hasan²,

Arshad³

et al. 2017

J. Med. Plants Res.

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In this study, the ability of Tinospora crispa aqueous extract (TCAE) to regulate cholesterol metabolism in human hepatoma cancer cell line (Hep G2) was determined. Cytotoxic study was performed by exposing hepatoma cell (Hep G2) towards TCAE with concentration ranging from 0.002 to 20 mg/ml for 24 h at 37°C and with 5% CO 2 atmosphere. Result revealed that TCAE was not toxic to the cell. The ability of TCAE to reduce cholesterol in cell culture experiment was carried out by pre-treating Hep G2 with selected concentrations of TCAE (10, 5, 2.5, 1.25 and 0.625 mg/ml) in 6-well plate before the cell was exposed to low density lipoprotein (LDL). The concentration of apolipoprotein A1 (Apo A1), lecithin-cholesterol acyltransferase (LCAT), low density lipoprotein receptor (LDLR), scavenger receptor B1 (SRB1) and hepatic Lipase (HL) which involve in reverse cholesterol transport (RCT) pathway were determined from the 6-well plate medium. The direct pathway of cholesterol synthesis was performed according to the instruction provided in HMG-CoA Reductase Assay Kit manuals. The results showed that TCAE significantly increase (p<0.05) the concentration of Apo A1, LCAT, LDLR, SRB-1 and HL. The efficacy of these activities is appreciably good when compared with standard drug simvastatin. However, TCAE showed moderate effect in controlling mevalonate pathway. These findings suggested that TCAE has the potential to reduce cholesterol metabolism in Hep G2 cancer cell lines and the pathway of TCAE action possibly more on RCT.

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Transintestinal cholesterol efflux

Cited by 119 publications

References 49 publications

Do clinical and experimental investigations support an antiatherogenic role for dietary phytosterols/stanols?

Do clinical and experimental investigations support an antiatherogenic role for dietary phytosterols/stanols?

Regulation of Intestinal Cholesterol Absorption: A Disease Perspective

Effects of Tinospora crispa aqueous extract in regulating cholesterol metabolism in human hepatoma cancer cell line (Hep G2)

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