Transient worsening of renal function during hospitalization for acute heart failure alters outcome

Logeart, Damien; Tabet, Jean-Yves; Hittinger, Luc; Thabut, Gabriel; Jourdain, Patrick; Maison, Patrick; Tartière, Jean-Michel; Solal, Alain Cohen

doi:10.1016/j.ijcard.2007.06.007

Cited by 118 publications

(107 citation statements)

References 25 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, the effects of decompensated CHF on kidney function are well known, 18 and the repercussions of AKI on cardiac function and mortality are being actively studied. [19][20][21][22][23] The bidirectional nature of these interactions may be mediated by vascular congestion, as classically observed in the cardiorenal syndrome. 18,24 In our study, patients hospitalized with a primary discharge diagnosis of CHF who experienced recurrent AKI were more likely to die than those who did not experience recurrent AKI (37% versus 26%).…”

Section: Discussionmentioning

confidence: 99%

Predictors of Recurrent AKI

Siew

Parr

Abdel-Kader

et al. 2016

Journal of the American Society of Nephrology

131

114

View full text Add to dashboard Cite

Recurrent AKI is common among patients after hospitalized AKI and is associated with progressive CKD. In this study, we identified clinical risk factors for recurrent AKI present during index AKI hospitalizations that occurred between 2003 and 2010 using a regional Veterans Administration database in the United States. AKI was defined as a 0.3 mg/dl or 50% increase from a baseline creatinine measure. The primary outcome was hospitalization with recurrent AKI within 12 months of discharge from the index hospitalization. Time to recurrent AKI was examined using Cox regression analysis, and sensitivity analyses were performed using a competing risk approach. Among 11,683 qualifying AKI hospitalizations, 2954 patients (25%) were hospitalized with recurrent AKI within 12 months of discharge. Median time to recurrent AKI within 12 months was 64 (interquartile range 19-167) days. In addition to known demographic and comorbid risk factors for AKI, patients with longer AKI duration and those whose discharge diagnosis at index AKI hospitalization included congestive heart failure (primary diagnosis), decompensated advanced liver disease, cancer with or without chemotherapy, acute coronary syndrome, or volume depletion, were at highest risk for being hospitalized with recurrent AKI. Risk factors identified were similar when a competing risk model for death was applied. In conclusion, several inpatient conditions associated with AKI may increase the risk for recurrent AKI. These findings should facilitate risk stratification, guide appropriate patient referral after AKI, and help generate potential risk reduction strategies. Efforts to identify modifiable factors to prevent recurrent AKI in these patients are warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

Predictors of Recurrent AKI

Siew

Parr

Abdel-Kader

et al. 2016

Journal of the American Society of Nephrology

131

114

View full text Add to dashboard Cite

show abstract

“…WRF during hospitalization can predict clinical outcomes in acute heart failure patients. 42, 43 However, few studies have evaluated the effect of WRF in the AMI population. 5 Our study results agree that WRF is an independent predictor for 2-year mortality after adjusting for multiple risk factors except the RIFLE classification (model 1).…”

Section: Hsieh Mj Et Almentioning

confidence: 99%

Renal Dysfunction on Admission, Worsening Renal Function, and Severity of Acute Kidney Injury Predict 2-Year Mortality in Patients With Acute Myocardial Infarction

Hsieh

Chen

et al. 2013

Circ J

View full text Add to dashboard Cite

“…Worsening renal function, defined as a change in serum creatinine ≥ 0.3 mg/mL during hospitalization, has been reported to be associated with an increased risk for long-term all cause/cardiovascular mortality and morbidity in AHF patients. 2,[21][22][23][24] In fact, in a retrospective study of 200,063 hospitalized AHF patients, Kociol, et al found that 17.8% developed worsening renal function, with 64.5% of these patients being readmitted and 35.4% dying within 1 year. After adjustment for patient characteristics, worsening renal function was independently associated with long-term mortality (HR 1.12, 95% CI: 1.04-1.20).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Prognostic Impact After Acute Kidney Injury in Patients With Acute Heart Failure

et al. 2012

View full text Add to dashboard Cite

SummaryThe relationship between the short-term prognosis of acute heart failure (AHF) and acute kidney injury (AKI) using the risk, injury, failure, and end stage (RIFLE) criteria has already been reported, however, the relationship between the long-term prognosis and AKI has not. We investigated the relationship between the long-term prognosis after discharge and AKI using the RIFLE criteria. Five hundred patients with AHF admitted to our intensive care unit were analyzed. Patients were assigned to a no AKI (n = 156), Class R (risk; n = 201), Class I (injury; n = 73), or Class F (failure; n = 70) using the most severe RIFLE classifications during hospitalization. We evaluated the relationships between the RIFLE classifications and any-cause death, and HF events including death and readmission for HF within 1 year. A multivariate logistic regression model found that Class I (P = 0.013, OR: 2.768; 95% CI: 1.236-6.199) and Class F (P < 0.001, OR: 7.920; 95% CI: 3.497-17.938) were independently associated with any-cause death, and Class F was associated with HF events (P = 0.001, OR: 3.486; 95% CI: 1.669-7

show abstract

Transient worsening of renal function during hospitalization for acute heart failure alters outcome

Cited by 118 publications

References 25 publications

Predictors of Recurrent AKI

Predictors of Recurrent AKI

Renal Dysfunction on Admission, Worsening Renal Function, and Severity of Acute Kidney Injury Predict 2-Year Mortality in Patients With Acute Myocardial Infarction

Long-Term Prognostic Impact After Acute Kidney Injury in Patients With Acute Heart Failure

Contact Info

Product

Resources

About