Transient Visual Symptoms Associated With Mellaril Medication

Morrison, Scott

doi:10.1176/ajp.116.11.1032-a

Cited by 11 publications

(2 citation statements)

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“…Morrison re¬ ported one case in which the patient com¬ plained of loss of dark adaptation and difficulty reading after receiving an average daily dose of 400 mg for 2i/¿ months, but no retinal pigmentation was noted in this case. 9 Heshe reported a case of retinal pigmenta¬ tion in a patient who received no more than 700 mg per day, but a total of 500 gm during a 2l/2-year period. Visual acuity was 6/12 and 6/9.e Brunold reported retinal pigmen¬ tation but no functional loss in a patient re¬ ceiving 150 mg per day for a long period.1 Brunold gave no details, but important addi¬ tional information has been supplied by Jenny, the consulting ophthalmologist,2 and is presented here for the first time with his permission :…”

Section: Commentmentioning

confidence: 99%

Retinal Pigmentation in a Patient Receiving Thioridazine

Scott¹

1963

Archives of Ophthalmology

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Section: Commentmentioning

confidence: 99%

Retinal Pigmentation in a Patient Receiving Thioridazine

Scott¹

1963

Archives of Ophthalmology

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“…of Psychiatry! University of pathy on very high dosage (39,20) akathisia) which is generally (12,16,30) but not invariably ( 17,38) much less frequent than with other phenothiazines. Epileptic seizures were reported by Barsa (4) in two of 100 chronic adult schizophrenic patients, neither of whom had been known to have seizures before and who had tolerated equal doses of chlorpromazine.…”

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confidence: 99%

A Controlled Study of the Use of Thioridazine in the Treatment of Hyperactive and Aggressive Children in a Children's Psychiatric Hospital

Alderton

Hoddinott²

1964

Canadian Psychiatric Association Journal

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It is now well recognized that the pa-that if an investigation is worth undertient response associated with the admini-taking there is no point in encouraging srration of medication has many deter-unlimited bias. minants. These include the staff involve-A second vital consideration in the dement and optimism which may be part sign of experiments into the effects of a of a drug investigation, the non-pharm-drug is the need for adequate, objective, acologically derived effect of the med-repeatable and quantifiable measures of ication (the so-called "placebo" effect), change. c?anges in the patient's interp~rsonal.enMuch current drug research is poorly vIronmentwhe0er at home or In hosl;">Ital, designed. Dunham and Howard (7) surwhether -occurrIng by ch~nc: or delIb.er-veyed six psychiatric journals for the fisately .t~rough therapeutI~mtervennon cal years 1957 and 1960 for articles rea~d clinical changes ;:flectII~g the natural porting research on the therapeutic value history of the condition being treated.of energizing and tranquillizing drugs. Gralnick (10) has pointed to the dan-They found that while the total number gers arising from a failure to take these of articles had increased by 36% in 1960, factors into account. Uncritical and ex-"most of the articles in both years and aggerated claims for a new treatment practically all of the increase fall at the method are likely to be followed by an lower levels of methodological adeequally uncritical rejection of the metho? quacy". Collaborative interdisciplinary as a whole, including any real value It research involving trained research workmight have. He warns that the same may ers was highly desirable in psychopharhappen with the new drugs unless they macology, in the authors' view. are subjected to thorough search and Thioridazine, first reported on, clinitudy a.n~unl~ss the treatment approach cally, in 1958 by Fleesan et «1 (8) and IS multidimensional from t?e start.Cohen (6) has since been the subject of !he use of the dou?le-bh~d procedure many reports. Doub.le-blind stud~es comUSIng placebo makes It poss~ble for most paring the drug with placebo In adult of these factors to be taken Into acco.unt, psychiatric patients (8, 14, 15, 29, 31, 1, since their influence will tend to contmue 11, 13) have all shown thioridazine to be whether the patient is taking placebo or more effective than placebo with few drug.side effects. The first five studies includNash (21), in his balanced appraisal of ed adequate objective measures of the double-blind procedure, emphasizes change. Further investigations employing the necessity for the investigator to "an-such measures, but without placebo, (23, ticipate damage to the experiment by fac-34, 37) concluded the drug was effective tors impeding attainment of double-blind and safe. Comparison with other phenoconditions, and to adapt his procedure to thiazines using placebo (8,9,11,14,31)

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Thioridazine Pigmentary Retinopathy

Davidorf¹

1973

Archives of Ophthalmology

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Transient Visual Symptoms Associated With Mellaril Medication

Cited by 11 publications

References 0 publications

Retinal Pigmentation in a Patient Receiving Thioridazine

Retinal Pigmentation in a Patient Receiving Thioridazine

A Controlled Study of the Use of Thioridazine in the Treatment of Hyperactive and Aggressive Children in a Children's Psychiatric Hospital

Thioridazine Pigmentary Retinopathy

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