Transient Vasopressin-Resistant Diabetes Insipidus of Pregnancy

Vasopressin and disorders of water balance: the physiology and pathophysiology of vasopressin

“…66 This must be di¡erentiated from the very rare transient NDI of pregnancy. 67 Selective vascular damage a¡ecting the inferior hypophyseal arteries (up to 20% of cases) and a primary autoimmune aetiology (up to 30%) have been identi¢ed in those patients previously described as having idiopathic HDI. 68 The autoimmune group is characterized by the presence of 69 The presence of circulating antibodies directed against VP-secreting cells is not speci¢c in isolation, and can occur as an epiphenomenon in patients with HDI from other causes.…”

Systemic Arterial Vasodilation, Vasopressin, and Vasopressinase in Pregnancy

“…In normal pregnancy, increased synthesis and release of vasopressin is adequate to maintain vasopressin plasma concentrations despite the increased activity of vasopressinase; however, in some pregnancies, increased levels of vasopressinase are associated with a transient diabetes insipidus. 13 This polyuric state is observed in women carrying multiple pregnancies, perhaps as a result of increased placental trophoblastic synthesis of vasopressinase. Transient diabetes insipidus of pregnancy also may occur with the liver involvement associated with preeclampsia, perhaps secondary to diminished hepatic degradation of vasopressinase.…”

Transient Nephrogenic Diabetes Insipidus Associated with Acute Hepatic Failure in Pregnancy

“…There are five reports of an association of transient nephrogenic diabetes insipidus in pregnancy (Ferrara et al, 1980;Barron et al, 1984;Goodman et al, 1984). All these five cases reveal elevated levels of liver enzymes without disturbance of consciousness or abnormalities of coagulation tests.…”