2014
DOI: 10.1172/jci76443
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Transient vascularization of transplanted human adult–derived progenitors promotes self-organizing cartilage

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Cited by 25 publications
(21 citation statements)
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“…They also reported that the onset of angiogenesis during the early stage of grafting is consistent with the timing of proliferation of MSCs. In fact, blocking of angiogenesis strongly inhibits the proliferation of cartilage progenitor cells and cartilage formation, and angiogenesis is essential for the proliferation of MSCs (cartilage precursor cells) derived from the perichondrium and their differentiation into chondrocytes [4]. In the current study, the timing of angiogenesis and that of proliferation of MSCs were consistent, whereas cartilage formation and the proliferation of the cartilage membrane were suppressed as a result of angiogenesis inhibition.…”
Section: Resultssupporting
confidence: 59%
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“…They also reported that the onset of angiogenesis during the early stage of grafting is consistent with the timing of proliferation of MSCs. In fact, blocking of angiogenesis strongly inhibits the proliferation of cartilage progenitor cells and cartilage formation, and angiogenesis is essential for the proliferation of MSCs (cartilage precursor cells) derived from the perichondrium and their differentiation into chondrocytes [4]. In the current study, the timing of angiogenesis and that of proliferation of MSCs were consistent, whereas cartilage formation and the proliferation of the cartilage membrane were suppressed as a result of angiogenesis inhibition.…”
Section: Resultssupporting
confidence: 59%
“…Based on the results of our study, the reason for the observed strong inhibition of perichondrial proliferation and cartilage formation by the MMP inhibitor compared to the VEGF-neutralizing antibody may have been not only the inhibition of angiogenesis, but also the inhibition of invasion of MMP-1-positive cells on days 1 to 3 post bFGF-treatment. Takebe et al found that early interactions with endothelial cells in establishing avascular tissues from human specific progenitors trigger the initial expansion of cartilage progenitor cells and promote the self-aggregation of a 3D condensation of progenitors without any scaffold materials in vitro, and the introduction of MSCs into immunodeficient mice results in angiogenesis within 3 days of grafting [4]. They also found that cartilage precursor cells proliferated from day 2 to 7 post-grafting, and that the grafted cells differentiated into chondrocytes from days 10 to 20 [4].…”
Section: Resultsmentioning
confidence: 99%
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“…The angiogenic potential of BMSCs has been identified and applied for revascularization of ischemic heart and limbs in patients; secretory VEGF produced from transplanted BMSCs played a critical role in inducing angiogenesis , . However, whether or not the angiogenic potential of BMSCs benefits chondrogenesis remains debatable owing to the avascular nature of cartilage , . Use of chondrocytes/chondrocyte bricks/PRP or silencing‐VEGF expression of BMSCs both caused central malnutrition in constructs, which presented as a necrotic cavity, limited GAG production, and poor morphological maintenance.…”
Section: Discussionmentioning
confidence: 99%