Transient tics aren't: Outcome of recent-onset tic disorder at one year

Kim, Soyoung; Greene, Deanna J.; Bihun, Emily C.; Koller, Jonathan M.; Hampton, Jackie; Acevedo, Haley; Reiersen, Angela M.; Schlaggar, Bradley L.; Black, Kevin J.

doi:10.31219/osf.io/aw5cu

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…All chronic tic disorders (CTD) begin at some point in time; it has not been clear which children with a recent-onset tic disorder would go on to develop a chronic tic disorder, and which would permanently remit. Kim and colleagues report on 43 children initially studied an average of 3 months after tic onset, of whom 39 returned at the 12-month anniversary of their first tic ( Kim et al ., 2018a; Kim et al ., 2019). Not surprisingly, symptoms had generally improved at the 12-month mark.…”

Section: Resultsmentioning

confidence: 99%

Tourette syndrome research highlights from 2018

et al. 2019

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This is the fifth yearly article in the Tourette Syndrome Research Highlights series, summarizing research from 2018 relevant to Tourette syndrome and other tic disorders. The authors briefly summarize reports they consider most important or interesting. The highlights from 2019 article is being drafted on the Authorea online authoring platform, and readers are encouraged to add references or give feedback on our selections using the comments feature on that page. After the calendar year ends, the article is submitted as the annual update for the Tics collection on F1000Research.

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Section: Resultsmentioning

confidence: 99%

Tourette syndrome research highlights from 2018

et al. 2019

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Provisional Tic Disorder is not so transient

Kim

Greene

Bihun

et al. 2019

Sci Rep

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Motor and vocal tics are common in childhood. The received wisdom among clinicians is that for most children the tics are temporary, disappearing within a few months. However, that common clinical teaching is based largely on biased and incomplete data. The present study was designed to prospectively assess outcome of children with what the current nomenclature calls Provisional Tic Disorder. We identified 43 children with recent onset tics (mean 3.3 months since tic onset) and re-examined 39 of them on the 12-month anniversary of their first tic. Tic symptoms improved on a group level at the 12-month follow-up, and only two children had more than minimal impairment due to tics. Remarkably, however, tics were present in all children at follow-up, although in several cases tics were apparent only when the child was observed remotely by video. Our results suggest that remission of Provisional Tic Disorder is the exception rather than the rule. We also identified several clinical features present at the first examination that predict one-year outcome; these include baseline tic severity, subsyndromal autism spectrum symptoms, and the presence of an anxiety disorder.

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Hippocampal volume in Provisional Tic Disorder predicts tic severity at 12-month follow-up

Kim

Greene

D’Andrea

et al. 2020

Preprint

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Background: Previous studies have investigated the relationships between the volumes of subcortical structures (e.g. caudate, putamen, thalamus, amygdala, hippocampus) and present tic symptom severity or future tic outcome in individuals with Tourette syndrome (TS). The largest such study found increased hippocampal volume in children with TS, but studies in adolescents and adults found the opposite. Subcortical volumes have not been studied in children in their first year after tic onset.Objective: This study aimed to examine whether the volumes of subcortical structures measured shortly after tic onset can predict tic symptom severity at the one-year anniversary of tic onset, when TS can first be diagnosed. Methods:We obtained T1-weighted structural MRI scans from 40 children (24 with prospective motion correction [vNavs]) whose tics had begun less than 9 months (median 3.7 months) prior to the first study visit (baseline). We re-examined them at the 12-month anniversary of their first tic (follow-up), assessing tic severity using the YGTSS. We quantified the volumes of subcortical structures using volBrain software.Results: Hippocampal volume measured at the baseline visit correlated with tic outcome at the 12-month follow-up, with a larger hippocampus at baseline predicting worse tic outcome at follow-up. The volumes of other subcortical structures did not predict tic outcome at follow-up.Conclusion: These findings suggest that hippocampal volume may be an important marker in predicting prognosis in Provisional Tic Disorder.

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Transient tics aren't: Outcome of recent-onset tic disorder at one year

Cited by 3 publications

References 35 publications

Tourette syndrome research highlights from 2018

Tourette syndrome research highlights from 2018

Provisional Tic Disorder is not so transient

Hippocampal volume in Provisional Tic Disorder predicts tic severity at 12-month follow-up

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