Transient synovitis of the hip: more evidence for a viral aetiology

Kastrissianakis, Katherina; Beattie, Tom F.

doi:10.1097/mej.0b013e32832b1664

Cited by 26 publications

(22 citation statements)

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“…This inflammation is painful and usually linked to osteoarthritis, rheumatoid arthritis or infections [3, 4, 6]. To alleviate pain and discomfort, the synovitis can be successfully treated with anti-inflammatory medications such as non-steroidal anti-inflammatory drugs [9] or biological therapies [10, 11, 14, 20].…”

Section: Discussionmentioning

confidence: 99%

“…This renewal is also facilitated by physical exercise and joint flexion [2]. The synovitis is an inflammation-related disease usually linked to rheumatoid arthritis [3], osteoarthritis [4, 5] and viral infections [6]. The inflammation of synovial tissue is accompanied to immune cells infiltration (mainly composed by macrophages and T and B lymphocytes) which initiates an inflammatory response causing pain and discomfort [7] and affecting the normal joint function [8].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of antigen-induced synovitis in a porcine model: Immunological, arthroscopic and kinetic studies

et al. 2017

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BackgroundSynovitis is an inflammation-related disease linked to rheumatoid arthritis, osteoarthritis, infections and trauma. This inflammation is accompanied by immune cells infiltration which initiates an inflammatory response causing pain, discomfort and affecting the normal joint function. The treatment of synovitis is based on the administration of anti-inflammatory drugs or biological agents such as platelet rich plasma and mesenchymal stem cells. However, the evaluation and validation of more effective therapies of synovitis requires the establishment of clinically relevant animal models.ResultsIn this study, Large White pigs were pre-immunized to evaluate an antigen-induced synovitis. The immune monitoring of synovial fluids in this model allowed us the identification of IL-12p40 and T cell subsets as immune biomarkers. Moreover, the evolution of synovitis was performed by arthroscopic procedures and kinetic analysis. In summary, this paper describes an animal model of antigen-induced synovitis to be used in the evaluation of anti-inflammatory therapies.ConclusionsThe novelty of this paper lies in the development of a clinically relevant model of synovitis which permits the simultaneous evaluation of synovitis from an immunological, surgical and kinetic point of view.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-017-1025-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of antigen-induced synovitis in a porcine model: Immunological, arthroscopic and kinetic studies

et al. 2017

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“…1 6 It is self limiting and is thought to follow a viral illness, although the evidence is weak. A recent small case-control study confirmed reports of recent viral illness in cases, 23 but information was prone to recall bias. Microbiological investigations have failed to identify a pathogen and the evidence for a viral aetiology comes from old studies that showed activation of the interferon system.…”

Section: Transient Synovitismentioning

confidence: 92%

Evaluating the child who presents with an acute limp

Perry

Bruce

2010

BMJ

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“…The male to female ratio is 2:1 for toxic synovitis and 4:1 for LP disease [ 98 ]. Although the pathogenesis of transient synovitis is still not completely clear, evidence indicates a viral etiology [ 99 ]. Treatment consists of rest and pain management, since transient synovitis is a self-limited condition with no known long-term sequelae.…”

Section: Transient Synovitismentioning

confidence: 99%