Transient synovitis of the hip in the child: Increased levels of proteoglycan fragments in joint fluid

Lohmander, L. Stefan; Wingstrand, Hans

doi:10.1002/jor.1100060313

Cited by 33 publications

(13 citation statements)

References 22 publications

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“…Accelerated degradation of proteoglycans in articular cartilage is characteristic of osteoarthritis and disuse atrophy (3,6,9,19,31,39), and, because elevated levels of keratan sulfate epitope also have been detected in synovial fluid from joints with inflammation (21,32), the keratan sulfate epitope probably is a general marker of proteoglycan degradation. Link protein was elevated in the synovial fluid lavages of the joints after transection of the anterior cruciate ligament, which is consistent with our previous studies (36,39).…”

Section: Discussionmentioning

confidence: 97%

Differential levels of synovial fluid aggrecan aggregate components in experimental osteoarthritis and joint disuse

Ratcliffe

Beauvais

Saed‐Nejad

1994

Journal Orthopaedic Research

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The levels of proteoglycan aggregate components (link protein, keratan sulfate epitope, and total sulfated glycosaminoglycan) were determined in the synovial fluid lavages of dogs with experimental osteoarthritis or disuse atrophy. A model of experimental osteoarthritis was created by transection of the anterior cruciate ligament of the right knee; studies were carried out 6 and 12 weeks after surgery. Joint disuse was studied at 4 and 8 weeks after initiation of the disuse. Recovery after disuse also was studied in joints that had 3 weeks of remobilization after 4 or 8 weeks of disuse. Synovial fluid lavages from the right knee joints of untreated animals were used as controls. The concentrations of keratan sulfate epitope, sulfated glycosaminoglycan, and link protein in the synovial fluid lavages at 6 and 12 weeks after transection of the anterior cruciate were elevated compared with the control values. Similar analysis of the fluid after disuse showed that the levels of keratan sulfate epitope and sulfated glycosaminoglycan were increased compared with the control levels and the levels after transection. However, the concentration of link protein in the fluid after disuse was not significantly different from the control level. The levels of keratan sulfate epitope and sulfated glycosaminoglycan in the synovial fluid lavages after disuse with recovery were high, but the levels of link protein remained low. The results indicate that the catabolism of proteoglycan aggregates in articular cartilage during early osteoarthritis and disuse is different. The determination of keratan sulfate epitope in synovial fluid lavages appears to provide a relatively general indication of proteoglycan catabolism, whereas increased levels of link protein may be more indicative of cartilage degeneration.

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Section: Discussionmentioning

confidence: 97%

Differential levels of synovial fluid aggrecan aggregate components in experimental osteoarthritis and joint disuse

Ratcliffe

Beauvais

Saed‐Nejad

1994

Journal Orthopaedic Research

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“…It is also increased in children with transient synovitis and septic arthritis (25). Increases in the cartilage proteoglycan content of synovial fluid may indicate a poor prognosis for future joint damage (30).…”

Section: Discussionmentioning

confidence: 99%

“…Since cartilage proteoglycans that have been partially degraded and released from articular cartilage can be detected in the joint fluids of patients with RA and osteoarthritis (5,9,25), it was of interest to determine whether the amount of circulating cartilage proteoglycans in the blood of patients with RA could be related to inflammation. Although fragments of cartilage proteoglycan are found in increased levels in some patients with osteoarthritis (7,8), this was not observed in RA (9).…”

mentioning

confidence: 99%

Inflammation and cartilage metabolism in rheumatoid arthritis. Studies of the Blood Markers Hyaluronic Acid, Orosomucoid, and Keratan Sulfate

Poole

Witter

Roberts

et al. 1990

Arthritis & Rheumatism

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Single analyses of peripheral blood of rheumatoid arthritis (RA) patients showed a significant reduction in the mean value for keratan sulfate (KS) compared with that in control subjects, but the mean value for orosomucoid (OM) was elevated compared with that in control subjects. Some RA patients displayed highly elevated levels of hyaluronic acid (HA), while others exhibited normal levels. There was a significant inverse correlation between OM and KS content in RA patients, as well as a direct correlation between HA and OM. In longitudinal studies of RA patients, parallel changes in OM and HA and inverse changes between KS and OM or HA were commonly observed. Clinical analyses revealed that there was an inverse correlation between KS and morning stiffness, and direct correlations between the number of tender joints and HA, and between HA or the erythrocyte sedimentation rate and the number of joints with effusions. The reason(s) for the inverse correlation between KS and OM as an index of systemic inflammation remains to be established. Circulating HA represents an index of joint inflammation, for which a marker has not been previously available.

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“…Previous studies showed that the concentration of KS in serum was on average slightly higher in osteoarthritic patients than in normals (357 (SD 73) ng/ml compared with 251 (78) ng/ml),25 and Saxne et al showed that for patients with acute arthritides the concentration of proteoglycans in synovial fluid fell on remission resulting from glucocorticoid treatment of the disease 8. Lohmander et al also noted increased concentration of proteoglycans in synovial fluid from hip joints of children with transient synovitis 29. …”

mentioning

confidence: 94%

Increased concentrations of proteoglycan components in the synovial fluids of patients with acute but not chronic joint disease.

Ratcliffe

Doherty

Maini

et al. 1988

Annals of the Rheumatic Diseases

132

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NottinghamSUMMARY Synovial fluid samples (139) from 121 patients with rheumatoid arthritis, osteoarthritis, pseudogout, chronic pyrophosphate arthritis, gout, and reactive arthritis were analysed for cartilage proteoglycan components. Keratan sulphate (KS) epitope was determined by a competitive radioimmunoassay, and total sulphated glycosaminoglycans (S-GAG) were determined after papain digestion by a specific dye binding assay. Increased concentration of both KS epitope and S-GAG were found in synovial fluid from joints with acute inflammatory arthropathy (gout, pseudogout, and reactive arthritis). Analysis of consecutive samples from the same joint at different stages showed that the concentration of KS epitope or total S-GAG varied with acute inflammatory activity. In samples from patients with chronic conditions during active and inactive inflammatory phases concentrations were much lower and not distinguishable among these disease groups. The detection of raised concentration of proteoglycan components may reflect the rapid depletion or greatly increased turnover of proteoglycan in the articular cartilage during acute inflammation in the joint. This did not appear to be sustained in most patients with chronic joint diseases.

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Transient synovitis of the hip in the child: Increased levels of proteoglycan fragments in joint fluid

Cited by 33 publications

References 22 publications

Differential levels of synovial fluid aggrecan aggregate components in experimental osteoarthritis and joint disuse

Differential levels of synovial fluid aggrecan aggregate components in experimental osteoarthritis and joint disuse

Inflammation and cartilage metabolism in rheumatoid arthritis. Studies of the Blood Markers Hyaluronic Acid, Orosomucoid, and Keratan Sulfate

Increased concentrations of proteoglycan components in the synovial fluids of patients with acute but not chronic joint disease.

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