Transient stress-related hyperviscosity and endothelial dysfunction in Takotsubo syndrome: a time course study

Marcucci, Rossella; Mannini, Lucia; Andrei, Valentina; Bandinelli, Brunella; Gori, Anna Maria; Fatucchi, Serena; Giglioli, Cristina; Romano, Salvatore Mario; Piazzai, Chiara; Marchionni, Niccolò; Cecchi, Emanuele

doi:10.1007/s00380-022-02071-6

Cited by 2 publications

(1 citation statement)

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“…The findings of this investigation support the theory that endothelial dysfunction and hyperviscosity play a role in the pathogenesis of TTS. Additionally, they imply that changes in erythrocyte deformability and endothelial dysfunction continue beyond the acute period and may be the focus of therapeutic techniques used to treat TTS [ 45 ].…”

Section: Pathophysiology Of Ttsmentioning

confidence: 99%

Takotsubo Syndrome: The Secret Crosstalk between Heart and Brain

Schino¹,

Bezzeccheri²,

Russo³

et al. 2023

Rev. Cardiovasc. Med.

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An acute, transient episode of left ventricular dysfunction characterizes Takotsubo syndrome. It represents about 2% of all cases of acute coronary syndrome (ACS), and occurs predominantly in postmenopausal women, generally following a significant physical or emotional stressor. It can be diagnosed based on clinical symptoms and the absence of coronary artery disease on angiography. Ventriculography remains the gold standard for the diagnosis. Despite its transitory characteristic Takotsubo syndrome should not be considered a benign condition since complications occur in almost half of the patients, and the mortality rate reaches 4-5%. Lately, it has been revealed that Takotsubo syndrome can also lead to permanent myocardial damage due to the massive release of catecholamines that leads to myocardial dysfunction. Different mechanisms have been advanced to explain this fascinating syndrome, such as plaque rupture and thrombosis, coronary spasm, microcirculatory dysfunction, catecholamine toxicity, and activation of myocardial survival pathways. Here are still several issues with Takotsubo syndrome that need to be investigated: the complex relationship between the heart and the brain, the risk of permanent myocardial damage, and the impairment of cardiomyocyte. Our review aims to elucidate the pathophysiology and the mechanisms underlying this complex disease to manage the diagnostic and therapeutic algorithms to create a functional synergy between physicians and patients.

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Section: Pathophysiology Of Ttsmentioning

confidence: 99%