Transient Serous Retinal Detachment in Classic and Occult Choroidal Neovascularization After Photodynamic Therapy

Mennel, Stefan; Meyer, Carsten H.; Eggarter, Fred; Peter, Silvia

doi:10.1016/j.ajo.2005.04.041

Cited by 28 publications

(19 citation statements)

References 6 publications

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“…Taken together, previous reports and our findings suggest that PDT is an effective treatment for CCH [1,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20]. Based on these reports it is also conceivable that PDT treatment for CCH is safe, although it may lead to the development of focal chorioretinal atrophy following either modified or standard treatment protocol, and might be associated with transient visual disturbances.…”

Section: Discussionmentioning

confidence: 49%

“…Here we describe the appearance of a transient scotoma and transient reduction of visual acuity as other possible complications of the treatment. Although the mechanism underlying visual symptoms in our patients is unclear, transient ischemia, increased exudation, transient damage to the retinal pigment epithelium, or breakdown in the outer blood-retinal barrier are possible explanations [17,18,19]. …”

Section: Discussionmentioning

confidence: 99%

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Application of the Standard Photodynamic Treatment Protocol for Symptomatic Circumscribed Choroidal Hemangioma

et al. 2006

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Purpose: To describe the results of photodynamic therapy (PDT) using a standard protocol, developed for treating choroidal neovascularization (CNV), for the treatment of circumscribed choroidal hemangioma (CCH). Methods: A prospective, uncontrolled, consecutive case series of patients with symptomatic CCH that were treated using the standard PDT protocol was evaluated periodically with ophthalmic exams and echography. Results: Nine CCH patients were included in the study. Mean tumor height decreased from 2.7 mm before treatment to 0.8 mm at the end of the follow-up period. Mean visual acuity improved from 6/15 to 6/12. Six patients required one PDT session, two patients two sessions, and one patient three sessions. Side effects included transient visual disturbances in two patients. One patient, who concomitantly presented with age-related macular degeneration, developed CNV. Conclusions: The standard PDT protocol is effective for the treatment of CCH. Complications are uncommon. Further studies should assess the optimal PDT protocol for the treatment of CCH.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Application of the Standard Photodynamic Treatment Protocol for Symptomatic Circumscribed Choroidal Hemangioma

et al. 2006

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“…In the previously mentioned study 12% of treated eyes developed this complication [12]. PDT may cause pathologic changes of the RPE and breakdown of the outer blood-retinal barrier [13,14,15]. This effect on the already damaged RPE, due to the age-related macular degeneration, may further deteriorate the junctions between the RPE cells and predispose to the development of an RPE tear.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Photodynamic Therapy in the Management of Occult Choroidal Neovascularization Associated with Serous Pigment Epithelium Detachment

Ladas¹,

Kotsolis²,

Rouvas³

et al. 2007

Ophthalmologica

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Aims: To evaluate the efficacy of photodynamic therapy (PDT) in the treatment of subfoveal occult choroidal neovascularization (CNV) associated with serous pigment epithelium detachment (PED) in eyes with age-related macular degeneration. Methods: Hundred and fifty-three patients (161 eyes) with subfoveal occult CNV due to age-related macular degeneration, were divided into two groups. The first group (70 patients, 75 eyes) included eyes with occult CNV associated with serous PED of at least 1 disc diameter in size and the second (83 patients, 86 eyes) eyes with late leakage of undetermined source. All the patients were treated with PDT. The follow-up time ranged from 12 to 48 months. Results: At the last examination, in the first group, the visual acuity (VA) improved or remained stable in 17 (22.7%) and decreased in 58 (77.3%). In the second group, the VA improved or remained stable in 37 (43%) and decreased in 49 (57%). The difference in the change (decrease) in the VA between the two groups was statistically very significant (p = 0.0075). Retinal pigment epithelium tear occurred in 15 eyes (20%) of the first group. Conclusion: Our study showed that the visual prognosis of eyes treated with PDT due to subfoveal occult CNV associated with serous PED is not favorable. We believe that the distinction between the two forms of occult CNV is essential, as they carry a different prognosis.

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“…Histological and electron microscopic examination of subretinal membranes removed after PDT revealed metaplastic changes in RPE [35]. Evaluation of the transient, PDT-induced neurosensory detachment showed that its size correlated more closely to the diameter of the laser treatment spot than to that of the CNV, suggesting that non-thermal laser may result in an outer BRB dysfunction causing transient retinal elevation [20]. Recently, persistent RPE cell destruction that was particularly evident in younger subjects was described using FA [27,38].…”

Section: Introductionmentioning

confidence: 97%

Effect of photodynamic therapy on the function of the outer blood-retinal barrier in an in vitro model

Mennel

Peter

Meyer

et al. 2006

Graefe's Arch Clin Exp Ophthalmo

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Transient Serous Retinal Detachment in Classic and Occult Choroidal Neovascularization After Photodynamic Therapy

Cited by 28 publications

References 6 publications

Application of the Standard Photodynamic Treatment Protocol for Symptomatic Circumscribed Choroidal Hemangioma

Application of the Standard Photodynamic Treatment Protocol for Symptomatic Circumscribed Choroidal Hemangioma

Efficacy of Photodynamic Therapy in the Management of Occult Choroidal Neovascularization Associated with Serous Pigment Epithelium Detachment

Effect of photodynamic therapy on the function of the outer blood-retinal barrier in an in vitro model

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