“…Although these studies demonstrated that metabolite accumulation was necessary for DEG toxicity (Besenhofer et al, 2010, 2011), EG (oxalate) accumulation was minimal and is now considered to be irrelevant for DEG toxicity. Although studies assessing the toxicity, pharmacokinetics, and biotransformation of DEG have been done using a variety of species including dogs, cats, mice, and rats (Winek et al, 1978; Lenk et al, 1989; Freundt and Weis, 1989; Wiener and Richardson, 1989; Mathews et al, 1991; Durand et al, 1976; Hebert at al., 1978; Harris, 1949), whether there is a sensitivity difference between Wistar and F-344 rats in renal toxicity or in DGA accumulation is yet unknown. Hence, this study was primarily designed to provide insight into an appropriate rat model by using a DEG dose response paradigm (0, 2, 5, or 10 g/kg) that covers the range of no to severe toxicity in Wistar rats (Besenhofer et al, 2010).…”