Transient receptor potential vanilloid 1 agonists modulate hippocampal CA1 LTP via the GABAergic system

Neural functions of calcineurin in synaptic plasticity and memory: Figure 1.

“…Together, these findings suggest that mGluR5 is likely an important mediator of CaN's action in memory regulation, through complex mechanisms that are still not fully understood. Some of the mechanisms by which mGluR5 contributes to LTD involve activation of the vanilloid receptor TrpV1 (Bennion et al 2011;Puente et al 2011). TrpV1 is a non-selective cation channel highly permeable to Ca 2+ and is also a direct target of CaN.…”

“…1; Mohapatra and Nau 2005). On a circuit level, this depends on whether Trpv1 is activated in excitatory or inhibitory neurons (Bennion et al 2011). Through an indirect mechanism involving LTD at inhibitory synapses, activation of TrpV1 can facilitate LTP (Bennion et al 2011) and suppress LTD in hippocampal networks.…”

“…On a circuit level, this depends on whether Trpv1 is activated in excitatory or inhibitory neurons (Bennion et al 2011). Through an indirect mechanism involving LTD at inhibitory synapses, activation of TrpV1 can facilitate LTP (Bennion et al 2011) and suppress LTD in hippocampal networks. This likely reflects differential action of Trpv1 on excitatory/inhibitory circuits, reminiscent of that observed for CaN (Lu et al 2000).…”

Alterations in CA1 pyramidal neuronal intrinsic excitability mediated by Ih channel currents in a rat model of amyloid beta pathology

“…Therefore, the present study by investigating the involvement of Ih channel current in the Aβ-induced AD alterations in the neuronal excitability and also by assessing the action of TRPV1 agonist and antagonist may provide insights for finding possible new targets for treatment of AD. 5 …”

Development and characterization of chronic animal models of schizophrenia

“…Several earlier studies suggested that TRPV1 receptors might play an important role in memory functions mainly at the hippocampal level, but the results are controversial [65,79,81,[177][178][179]. TRPV1 receptor activation can modify both LTP and long term depression (LTD) at the hippocampal level, and LTP is damaged in TRPV1-deficient mice [81,178,180]. Since both LTP and LTD are presumed to play a part in the establishment of stable memories, the manipulation of TRPV1 receptors can influence these processes [79,181,182].…”