Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases

Dietrich, Alexander; Steinritz, Dirk; Gudermann, Thomas

doi:10.1016/j.ceca.2017.04.005

Cited by 52 publications

(49 citation statements)

References 231 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In brief, HNECs were treated with LPS (serving as a proxy for invading bacterial pathogens) alone or with the TRPC6 inhibitor SKF–96365 or the TRPC6 activator OAG. We found that TRPC6, STIM1, Orai1, Ca 2+ MFI, and inflammatory mediators were significantly elevated by LPS or OAG but were decreased by SKF‐96365, demonstrating that LPS acting as an invading bacterial pathogen or OAG functioning as TRPC6 activator may induce TRPC6 activation, and inhibition of TRPC6 may alleviate the effect, which is consistent with the results of a previous study …”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Pro‐inflammatory role of transient receptor potential canonical channel 6 in the pathogenesis of chronic rhinosinusitis with nasal polyps

Tang

et al. 2018

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 92%

“…Recent studies have suggested that TPRC6 and TRPC6‐dependent Ca 2+ influx contribute to the inflammatory response in bronchial epithelial cells and lung endothelial cells, thereby leading to chronic airway inflammatory diseases . However, whether TPRC6 contributes to the genesis and development of CRSwNP remains unknown.…”

mentioning

confidence: 99%

Pro‐inflammatory role of transient receptor potential canonical channel 6 in the pathogenesis of chronic rhinosinusitis with nasal polyps

Tang

et al. 2018

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

show abstract

“…TRP channels are expressed primarily by neurons [16,17]. At the same time, some channels have also been found on other cells, in particular on cells of the respiratory tract (bronchial epithelium and endothelium, smooth muscle cells, non-myelinated nociceptive C-fibers of the lungs) [17,18]. TRPA1, TRPV, TRPC, TRPM expressed in the respiratory tract are the most studied.…”

Section: Characterization Of Trp Ion Channels Localized In the Bronchmentioning

confidence: 99%

Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma

et al. 2020

View full text Add to dashboard Cite

Asthma is a chronic heterogeneous disease characterized by chronic inflammation and bronchial hyperreactivity. Neurogenic inflammation is one of the important causes of hyperreactivity. Dysfunction of transient receptor potential (TRP) ion channels underlies the development of neurogenic inflammation, bronchial hyperreactivity and respiratory symptoms of asthma such as bronchospasm and cough. TRP channels are expressed in the respiratory tract. Their activation is mediated by endogenous and exogenous factors involved in the pathogenesis of asthma. The study of functioning and regulation of TRP channels is relevant, as they could be important therapeutic targets for asthma. The aim of the review is to summarize modern ideas about the mechanisms of functioning and regulation of members of the TRP channel superfamily, the role of which in lung pathology and physiology are the best studied.

show abstract

“…) (Dietrich et al . ). ROS are important mediators of endothelial barrier dysfunction in pathologies such as ARDS, ischaemia–reperfusion and hyperoxia (Christofidou‐Solomidou & Muzykantov, ) and promote interendothelial gap formation at least in part by stimulating Ca 2+ entry into endothelial cells to (Cioffi, ).…”

Section: Introductionmentioning

confidence: 97%

Novel mechanisms regulating endothelial barrier function in the pulmonary microcirculation

Simmons

Erfinanda

Bartz

et al. 2018

The Journal of Physiology

View full text Add to dashboard Cite

The pulmonary epithelial and vascular endothelial cell layers provide two sequential physical and immunological barriers that together form a semi-permeable interface and prevent alveolar and interstitial oedema formation. In this review, we focus specifically on the continuous endothelium of the pulmonary microvascular bed that warrants strict control of the exchange of gases, fluid, solutes and circulating cells between the plasma and the interstitial space. The present review provides an overview of emerging molecular mechanisms that permit constant transcellular exchange between the vascular and interstitial compartment, and cause, prevent or reverse lung endothelial barrier failure under experimental conditions, yet with a clinical perspective. Based on recent findings and at times seemingly conflicting results we discuss emerging paradigms of permeability regulation by altered ion transport as well as shifts in the homeostasis of sphingolipids, angiopoietins and prostaglandins.

show abstract

Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases

Cited by 52 publications

References 231 publications

Pro‐inflammatory role of transient receptor potential canonical channel 6 in the pathogenesis of chronic rhinosinusitis with nasal polyps

Pro‐inflammatory role of transient receptor potential canonical channel 6 in the pathogenesis of chronic rhinosinusitis with nasal polyps

Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma

Novel mechanisms regulating endothelial barrier function in the pulmonary microcirculation

Contact Info

Product

Resources

About