Transient Receptor Potential (TRP) Channels in Haematological Malignancies: An Update

Maggi, Federica; Morelli, Maria Beatrice; Nabissi, Massimo; Marinelli, Oliviero; Zeppa, Laura; Aguzzi, Cristina; Santoni, Giorgio; Amantini, Consuelo

doi:10.3390/biom11050765

Cited by 8 publications

(8 citation statements)

References 124 publications

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“…Few data are present about the involvement of TRP channels in hematological malignancies. The expression of several members of the TRP family in different lymphoid and myeloid leukemia has been demonstrated 5,6 . In fact, it has been shown that TRPV5 and 6‐induced [Ca 2+ ] i stimulates cell cycle arrest in myeloid leukemia cell lines 7 .…”

Section: Introductionmentioning

confidence: 99%

“…The expression of several members of the TRP family in different lymphoid and myeloid leukemia has been demonstrated. 5 , 6 In fact, it has been shown that TRPV5 and 6‐induced [Ca 2+ ] i stimulates cell cycle arrest in myeloid leukemia cell lines. 7 The inhibition of TRPM7 reduces cell proliferation and promotes erythroid differentiation in K562 CML cells.…”

Section: Introductionmentioning

confidence: 99%

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The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib

et al. 2022

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“…It is thought that the primary physiological roles of TRP channels are perception of various sensations ranging from pain, pressure, temperature, taste and vision. However, evidence accumulates that TRP channels also regulate proliferation, differentiation, invasion, metastasis, autophagy and apoptosis of malignant cells (80,81,(166)(167)(168)(169)(170). TRP channels have been shown to contribute crucial oncogenic functions in a number of hematologic malignancies (166,167).…”

Section: Transient Receptor Potential Channelsmentioning

confidence: 99%

“…However, evidence accumulates that TRP channels also regulate proliferation, differentiation, invasion, metastasis, autophagy and apoptosis of malignant cells (80,81,(166)(167)(168)(169)(170). TRP channels have been shown to contribute crucial oncogenic functions in a number of hematologic malignancies (166,167). Leukemia, lymphoma, myeloma and Waldenström macroglobulinaemia patient cells and cell lines have altered expression of TRP channels that has been linked with changes in cell proliferation, cell death and cell migration (165-167) (Table 1).…”

Section: Transient Receptor Potential Channelsmentioning

confidence: 99%

Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential

Immanuel

Li²,

Green³

et al. 2022

Front. Oncol.

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Intracellular calcium signaling regulates diverse physiological and pathological processes. In solid tumors, changes to calcium channels and effectors via mutations or changes in expression affect all cancer hallmarks. Such changes often disrupt transport of calcium ions (Ca2+) in the endoplasmic reticulum (ER) or mitochondria, impacting apoptosis. Evidence rapidly accumulates that this is similar in blood cancer. Principles of intracellular Ca2+ signaling are outlined in the introduction. We describe different Ca2+-toolkit components and summarize the unique relationship between extracellular Ca2+ in the endosteal niche and hematopoietic stem cells. The foundational data on Ca2+ homeostasis in red blood cells is discussed, with the demonstration of changes in red blood cell disorders. This leads to the role of Ca2+ in neoplastic erythropoiesis. Then we expand onto the neoplastic impact of deregulated plasma membrane Ca2+ channels, ER Ca2+ channels, Ca2+ pumps and exchangers, as well as Ca2+ sensor and effector proteins across all types of hematologic neoplasms. This includes an overview of genetic variants in the Ca2+-toolkit encoding genes in lymphoid and myeloid cancers as recorded in publically available cancer databases. The data we compiled demonstrate that multiple Ca2+ homeostatic mechanisms and Ca2+ responsive pathways are altered in hematologic cancers. Some of these alterations may have genetic basis but this requires further investigation. Most changes in the Ca2+-toolkit do not appear to define/associate with specific disease entities but may influence disease grade, prognosis, treatment response, and certain complications. Further elucidation of the underlying mechanisms may lead to novel treatments, with the aim to tailor drugs to different patterns of deregulation. To our knowledge this is the first review of its type in the published literature. We hope that the evidence we compiled increases awareness of the calcium signaling deregulation in hematologic neoplasms and triggers more clinical studies to help advance this field.

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“…Breast cancer progression is reported to be supported by TRPV6 and more so by the gain-of-function R532Q mutant of TRPV6 ( 2 ). TRP channel overexpression has also been implicated in hematopoietic malignancies such as leukemia and lymphoma ( 3, 4 ). In colorectal cancers, TRP channels are reported to be overexpressed and responsible for facilitating metastasis ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides

Achimba,

Faezov,

Cohen

et al. 2023

Molecular Cancer Therapeutics

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The regulation of cellular processes by ion channels has become central to the study of cancer mechanisms. Designing molecules that can modify ion channels specific to tumor cells is a promising area of targeted drug delivery and therapy. Despite their potential in drug discovery, venom peptides – a group of natural products – have largely remained understudied and under-characterized. In general, venom peptides display high specificity and selectivity for target ion channels. Therefore, they may represent an effective strategy for selectively targeting the dysregulation of ion channels in tumor cells. This review examines existing venom peptide therapies for different cancer types and focuses on the application of snail venom peptides in hepatocellular carcinoma (HCC), the most common form of primary liver cancer worldwide. We provide insights into the mode of action of venom peptides that have been shown to target tumors. We also explore the benefit of using new computational methods like de novo protein structure prediction to screen venom peptides and identify potential druggable candidates. Finally, we summarize the role of cell culture, animal, and organoid models in developing effective therapies against HCC and highlight the need for creating models that represent the most disproportionately affected ethnicities in HCC.

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Transient Receptor Potential (TRP) Channels in Haematological Malignancies: An Update

Cited by 8 publications

References 124 publications

The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib

The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib

Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential

Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides

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