2022
DOI: 10.3390/ani12010106
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Transient Receptor Potential (TRP) and Thermoregulation in Animals: Structural Biology and Neurophysiological Aspects

Abstract: This review presents and analyzes recent scientific findings on the structure, physiology, and neurotransmission mechanisms of transient receptor potential (TRP) and their function in the thermoregulation of mammals. The aim is to better understand the functionality of these receptors and their role in maintaining the temperature of animals, or those susceptible to thermal stress. The majority of peripheral receptors are TRP cation channels formed from transmembrane proteins that function as transductors throu… Show more

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Cited by 27 publications
(25 citation statements)
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“…Although the importance of shivering thermogenesis is evident, reports on newborn lambs suggest that around 50% of heat production comes from shivering thermogenesis and 50% from non-shivering thermogenesis ( 90 ). This may be mainly attributable to the anatomical magnitude of the newborn, that is, the degree of muscle development ( 84 , 91 ).…”
Section: Thermoregulation Mechanisms To Combat Hypothermia In Ruminantsmentioning
confidence: 99%
See 1 more Smart Citation
“…Although the importance of shivering thermogenesis is evident, reports on newborn lambs suggest that around 50% of heat production comes from shivering thermogenesis and 50% from non-shivering thermogenesis ( 90 ). This may be mainly attributable to the anatomical magnitude of the newborn, that is, the degree of muscle development ( 84 , 91 ).…”
Section: Thermoregulation Mechanisms To Combat Hypothermia In Ruminantsmentioning
confidence: 99%
“…Within the thermoregulatory system of newborns, the activation of peripheral thermoreceptors such as transient potential receptors (TPR) is the first step to initiating every thermal response. The key role of these receptors, particularly TRPA1, TRPM8, and TRPC5 are triggered by cold stimuli and promote the vasomotor changes or contraction of skeletal muscle ( 91 ). However, to date, the available data is focused on small rodents.…”
Section: Perspectivesmentioning
confidence: 99%
“…Thermoregulation plays an important role in newborns, especially in altricial species [ 6 ]. Through its extensive dermal vascularization, the body avoids losing temperature by producing changes in the blood flow of specific body regions [ 7 ], which are called biological thermal windows [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…The βTRPM clade contains the TRPM2 , TRPM4 , TRPM5, and TRPM8 , where the TRPM2 , TRPM4, and TRPM5 are activated by heat, but the TRPM8 responds to cold temperatures [ 55 ]. TRPV proteins belong to two groups that assist with this function, TRPV1-4 proteins are defined as thermosensitive [ 46 ], and TRPV5/6 proteins’ function is to maintain Ca 2+ homeostasis [ 47 ]. In lizards, TRPP channels are organized into PKD1-like and PKD2-like, except for the brivido subfamily, which differs from the previous studies [ 54 , 56 ].…”
Section: Discussionmentioning
confidence: 99%
“…Based on the previous research [ 12 , 47 ], we selected seven genes, including TRPA1, TRPM8, TRPC5, and TRPV1-4, to analyze the selection pressure in the eight saurian genomes, and then calculated the proportions of the non-synonymous ( d N)/synonymous ( d S) evolutionary rate (ω) using EasyCodeML v1.12 [ 48 ] to represent the selective selection. Different ω values indicated a different type of selection: ω > 1 shows the positive selection, ω = 1 represents the neutral selection, and ω < 1 represents the purifying selection [ 49 ].…”
Section: Methodsmentioning
confidence: 99%