Transient receptor potential melastatin 8 gene polymorphism is associated with cold‐induced airway hyperresponsiveness in bronchial asthma

Naumov, Denis; Perelman, Juliy M.; Кolosov, Victor P.; Потапова, Т. А.; Maksimov, V. N.; Zhou, Xiangdong

doi:10.1111/resp.12605

Cited by 25 publications

(20 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The Asia Pacific region contains extremes of environmental temperatures, and many of our patients suffer from cold‐induced bronchoconstriction. This phenomenon was investigated by a group from Russia and China and reported in Respirology . Although we all feel the cold, have you ever thought ‘how’ we feel the cold?…”

Section: Asthmamentioning

confidence: 99%

See 1 more Smart Citation

Year in review 2015: Asthma and chronic obstructive pulmonary disease

et al. 2016

View full text Add to dashboard Cite

Asthma continues to cause substantial morbidity and mortality, affecting some 300 million people worldwide, with a large proportion of those poorly controlled.1-3 In the last year, Respirology published a broad-based range of papers focusing on this important disease, ranging from questionnaire studies to molecular biology in mouse models. 4,5 This range of papers emphasizes the breadth of asthma research underway and the role of Respirology in disseminating these advances.

show abstract

Section: Asthmamentioning

confidence: 99%

“…This phenomenon was investigated by a group from Russia and China and reported in Respirology. 16 Although we all feel the cold, have you ever thought 'how' we feel the cold? Part of the story is via receptors called transient receptor potential melastatin channels (TRPM), specifically type 8 of the family.…”

Section: Environment As a Trigger Of Lung Diseasementioning

confidence: 99%

Year in review 2015: Asthma and chronic obstructive pulmonary disease

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Cold-air inhalation causes airway constriction and can induce asthma associated with, for instance, winter sports. 107,108 These observations suggest the implication of TRPM8 channels both in physiological and pathological respiratory processes.…”

Section: Trpm8 In Other Pathological Conditionsmentioning

confidence: 84%

“…107,108,242 Although ion channels remain underexploited in drug development, continued investigation into the discovery of new, selective TRPM8 agonists and antagonists will undoubtedly contribute to future progress in the field. The ability to combine advances in functional screening, biophysical characterization, and structure-based design techniques, along with the generation of new chemical space to target ion channels will constitute a substantial challenge for the drug discovery community in the following decade.…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer

et al. 2016

View full text Add to dashboard Cite

Abstract. TRPM8 ion channels, the primary cold sensors in humans, are activated by innocuous cooling (< 28 ºC) and cooling compounds (menthol, icilin), and are implicated in sensing unpleasant cold stimuli, as well as in mammalian thermoregulation. Over-expression of these thermoregulators in prostate cancer and in other life-threatening tumors, along with their contribution to an increasing number of pathological conditions, opens a plethora of medicinal chemistry opportunities to develop receptor modulators. This Perspective seeks to compile current known modulators for this ion channel, since both agonists and antagonists may be useful for the treatment of most TRPM8-mediated pathologies. We primarily focus on SAR data for the different families of compounds and the pharmacological properties of the most promising ligands. Furthermore, we also address the knowledge about the channel structure, although still in its infancy, and the role of the TRPM8 protein signalplex to channel function and dysfunction. We finally outline the potential future prospects of the challenging TRPM8 drug discovery field.

show abstract

“…Показано, что данный класс рецепторов экспрессиру-ется на нервных окончаниях респираторного тракта [14] и на бронхиальном эпителии [17], где способен опосредовать нервно-рефлекторную бронхоконстрик-цию и местные воспалительные реакции в ответ на охлаждение. Ранее нами уже была установлена роль полиморфизма c.750G>C (rs11562975) гена TRPM8 в формировании ХГДП у больных БА [10] . Целью настоящего исследования явилась верифи-кация результатов ассоциативного анализа однонуклео-тидного полиморфизма c.750G>C (rs11562975) с ХГДП, а также поиск других вариантов гена TRPM8, возможно, связанных с данным феноменом.…”

unclassified

Role of Trpm8 Gene Polymorphisms in the Formation of Asthma Phenotype With Cold Airway Hyperresponsiveness

Naumov¹,

Котова²,

Kotova

et al. 2017

Bulletin Physiology and Pathology of Respiration

View full text Add to dashboard Cite

The aim of the study was to evaluate the effect of TRPM8 cold thermoreceptor gene polymorphisms on the development of asthma phenotype with cold airway hyperresponsiveness (CAH). 167 cases of mild-to-moderate persistent asthma were retrospectively analyzed. In each case, the examination included two repeated bronchoprovocation tests with 3-min isocapic cold air hyperventilation with 6-month interval, standard spirometry and genotyping of seven TRPM8 polymorphisms (rs11562975, rs17868387, rs28901637, rs138810119, rs2052030, rs17865682 and rs1003540). A double positive response to the bronchoprovocation test served as a criterion for the phenotype of asthma with CAH. Based on the results of the study, previously revealed relationship between rs11562975 polymorphism and CAH was confirmed, and also three new polymorphisms (rs17868387, rs17865682 and rs1003540) differentially associated with CAH asthma phenotype were identified. The obtained data indicate the contribution of the molecular genetic peculiarities of TRPM8 to the pathogenesis of CAH and substantiate the further search for additional molecular mechanisms of cold-induced respiratory reactions.

show abstract

Transient receptor potential melastatin 8 gene polymorphism is associated with cold‐induced airway hyperresponsiveness in bronchial asthma

Abstract: The GC variant of the TRPM8:c.750G > C (rs11562975) polymorphism is associated with CAH in patients with BA, which suggests a potential role of TRPM8 in CAH development.

Cited by 25 publications

References 18 publications

Year in review 2015: Asthma and chronic obstructive pulmonary disease

Year in review 2015: Asthma and chronic obstructive pulmonary disease

Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer

Role of Trpm8 Gene Polymorphisms in the Formation of Asthma Phenotype With Cold Airway Hyperresponsiveness

Contact Info

Product

Resources

About