Transient receptor potential melastatin-7 in the rat dorsal root ganglion

Yajima, Takahiro; Sato, Tadasu; Hosokawa, Hiroshi; Kondo, Teruyoshi; Ichikawa, Hiroyuki

doi:10.1016/j.jchemneu.2022.102163

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…The transient receptor potential cation channel subfamily V member 1 (TRPV1) responds to heat > 43°C, protons, and capsaicin (Caterina et al 1997). Small-and medium-sized sensory neurons in the sensory ganglia of the trigeminal ganglion (TG), glossopharyngeal ganglion (PG), and vagus nerves (jugular ganglion (JG) and NG) express TRPV1 (Guo et al 1999;Ichikawa and Sugimoto 2001;Hironaka et al 2014;Sato et al 2021;Yajima et al 2022). These neurons send free nerve endings to the peripheral receptive fields (Pei et al 2007;Rodd et al 2007;Sasaki et al 2013).…”

Section: Methodsmentioning

confidence: 99%

Distribution and anti-nociceptive function of endomorphin-1 in the rat cranial sensory ganglia

SATO,

YAJIMA

et al. 2024

Biomed. Res.

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Distribution of endomorphin-1 (EM-1) was immunohistochemically investigated in the rat cranial sensory ganglia. Small to medium-sized neurons in the trigeminal (TG), petrosal (PG), and jugular ganglia (JG) expressed EM-1-immunoreactivity. However, EM-1-immunoreactive (-ir) neurons were infrequent in the nodose ganglion. In the brainstem, EM-1-ir varicose fibers were detected in the superficial layer of the medullary dorsal horn and the caudal part of the nucleus tractus solitarius. By trichrome immunofluorescence analysis, approximately 70% of EM-1-ir neurons were also immunoreactive for transient receptor potential vanilloid 1 (TRPV1) in all the examined ganglia. Additionally, 56.8% of EM1-ir TG neurons and approximately 30% of EM-1-ir PG and JG neurons showed calcitonin gene-related peptide (CGRP)-immunoreactivity. By a retrograde tracing method, several TG, PG, and JG neurons innervating the facial and external ear canal skin expressed EM-1-immunoreactivity. However, EM-1-ir neurons innervating the tooth pulp, circumvallate papilla, and pharynx were relatively rare. Thus, EM-1 expression and its coexistence with TRPV1 and CGRP in the cranial sensory neurons may depend on their various peripheral targets. EM1-ir neurons probably project to the superficial layer of the medullary dorsal horn and caudal part of the nucleus tractus solitarius. EM-1 may be involved in nociceptive transmission from the skin.

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