1988
DOI: 10.1098/rspb.1988.0037
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Transient potassium current in native Xenopus oocytes

Abstract: Depolarization of follicle-enclosed oocytes of Xenopus laevis obtained from some donors elicits, in addition to other responses, a fast transient outward current. After holding the membrane potential at –100 mV this response begins to be activated by depolarizations to around –30 mV, and increases progressively as the voltage is raised further. A striking characteristic is that the current recovers only slowly (several seconds) from inactivation following a depolarizing pulse. Because o… Show more

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Cited by 19 publications
(2 citation statements)
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“…1987). In this case, we point out that the K+ response's sensitivity to defolliculation would have to be highly selective since the muscarinic oscillatory Cl-response, Tout current, Ca2'-independent Cl-current (Parker & Miledi, 1988a), fast and slowly desensitizing K+ currents (Parker & Miledi, 1988b;authors' unpublished results) and at least two differenit types of Na+ currents (Baud, Kado & Marcher, 1982;Parker & Miledi, 1987) Locating cyclic nucleotide-activated K+ channels in the follicular compartment corresponds with evidence, both direct and indirect, suggesting that receptors which mediate K+ responses are also located in follicular cells, for example:…”
Section: Discussionmentioning
confidence: 99%
“…1987). In this case, we point out that the K+ response's sensitivity to defolliculation would have to be highly selective since the muscarinic oscillatory Cl-response, Tout current, Ca2'-independent Cl-current (Parker & Miledi, 1988a), fast and slowly desensitizing K+ currents (Parker & Miledi, 1988b;authors' unpublished results) and at least two differenit types of Na+ currents (Baud, Kado & Marcher, 1982;Parker & Miledi, 1987) Locating cyclic nucleotide-activated K+ channels in the follicular compartment corresponds with evidence, both direct and indirect, suggesting that receptors which mediate K+ responses are also located in follicular cells, for example:…”
Section: Discussionmentioning
confidence: 99%
“…1. The total membrane conductance consists of at least three major specific components; passive conductances for CI-(see, e.g., Robinson, 1979;Miledi, 1982;Barish, 1983;Peres & Bernardini, 1983;Parker & Miledi, 1988a) and K § (see, e.g., Peres et a1.,1985;Parker & Miledi, 1988b;Schweigeft, Lafaire & Schwarz, 1988), and the electrogenic contribution of the 3 Na+/2 K § pump (Lafaire & Schwarz, 1986). Figure IA demonstrates that the phorbol ester PMA, known to stimulate activity of protein kinase C (Castagna et al, 1982;Nishizuka, 1984), induces a gradual decrease of total membrane current at all membrane potentials.…”
Section: Conduclancementioning
confidence: 99%