Transient phlebitis induced by a bolus injection of propofol

Kinoshita, Hiroyuki; Kakutani, Tetsuya; Minonishi, Toshiyuki; Mizumoto, Kazuhiro; Hatano, Yoshio

doi:10.1007/s00540-005-0364-7

Cited by 5 publications

(8 citation statements)

References 1 publication

(1 reference statement)

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“…After injecting lipid emulsion propofol (Diprivan®), the incidence of phlebitis is reported as below 6.6% [23], and in this study, one person each was observed in the control and sufentanil 0.1 µg/kg pretreatment group, for whom the incidence of phlebitis was 2.5% 24 hours after the surgery. Both suffered from severe injection pain, and as a result of observing the vein after replacing injection area, they improved without aggravation.…”

Section: Discussionmentioning

confidence: 75%

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The effect and optimal dose of sufentanil in reducing injection pain of microemulsion propofol

Chung

Kim

Lee

et al. 2011

Korean J Anesthesiol

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BackgroundPropofol is used as an induction and maintenance agent for general anesthesia but it can cause adverse reactions like hyperlipidemia, growth of microorganisms, and pulmonary embolisms. Microemulsion propofol was developed to avoid these side effects but incidence and severity of pain on injection is higher than with lipid emulsion propofol. We aimed to compare the effects of sufentanil in analgesic doses for reducing the injection pain of microemulsion propofol.MethodsThe candidates included eighty patients, 19-60 years old and ASA I-II. They were randomly classified into four groups and pretreated with normal saline, sufentanil 0.1 µg/kg, 0.2 µg/kg or 0.3 µg/kg before injection of microemulsion propofol. Five minutes after receiving pretreatment drug, 2 mg/kg of microemulsion propofol was injected and VAS was recorded.ResultsThere were no significant differences in the incidence of injection pain among the groups. Severity of injection pain was significantly lower in the sufentanil 0.3 µg/kg group than normal saline and sufentanil 0.1 µg/kg group. Significant differences in blood pressure and heart rate were observed in sufentanil groups only after endotracheal intubation. One patient each in sufentanil 0.1 µg/kg and 0.3 µg/kg group experienced mild cough, one from sufentanil 0.3 µg/kg group experienced dizziness and another showed signs of hypoxia. One patient each in normal saline and sufentanil 0.1 µg/kg group showed clinical symptoms of phlebitis in the injection area.ConclusionsPretreatment with sufentanil 0.3 µg/kg reduced the severity of microemulsion propofol injection pain without increasing arterial blood pressure and heart rate after endotracheal intubation.

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Section: Discussionmentioning

confidence: 75%

“…Both suffered from severe injection pain, and as a result of observing the vein after replacing injection area, they improved without aggravation. However, this phlebitis might have occurred without injection pain [23], so it is important to carefully monitor the injection area after the injection.…”

Section: Discussionmentioning

confidence: 99%

The effect and optimal dose of sufentanil in reducing injection pain of microemulsion propofol

Chung

Kim

Lee

et al. 2011

Korean J Anesthesiol

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“…There have been several other reports of a TRP occurring after initiation of a medication drip, though none have reported vancomycin as a causative agent. Previously reported medications include morphine, pethidine, rocuronium, propofol, ciprofloxacin, diphenhydramine, and eptifibatide [5][6][7][8][9][10][11][12][13]. TRP is isolated to the recipient extremity and occurs downstream to the infusing intravenous cannula [5,[10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…Previously reported medications include morphine, pethidine, rocuronium, propofol, ciprofloxacin, diphenhydramine, and eptifibatide [5][6][7][8][9][10][11][12][13]. TRP is isolated to the recipient extremity and occurs downstream to the infusing intravenous cannula [5,[10][11][12][13]. Symptoms include a vermiform rash comprising the region of phlebitis and may be associated with mild pain [5][6][7][8]10,13].…”

Section: Discussionmentioning

confidence: 99%

"Getting Under Your Skin”: First Reported Case of Transient Reactive Phlebitis Involving Vancomycin Infusion Therapy

Azimi-Ghomi

Napier²

2021

Cureus

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“…It is with interest that I read the recent report by Kinoshita et al [2], describing an elderly surgical patient who developed transient phlebitis induced by an intraoperative intravenous bolus injection of propofol. I tend to agree with the authors that the incidence of this complication in the clinical practice of anesthesiology might be underreported.…”

mentioning

confidence: 96%