Transient pancytopenia preceding acute lymphoblastic leukaemia (pre‐ALL) precipitated by parvovirus B19

Heegaard, Erik D.; Madsen, Hans O.; Schmiegelow, Kjeld

doi:10.1046/j.1365-2141.2001.03021.x

Cited by 32 publications

(32 citation statements)

References 19 publications

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“…However, several reports describe B19 infection preceding and mimicking ALL. [1][2][3][4] One published study examined serum from 65 patients with ALL for B19 DNA and specific IgG. 5 The results showed that although there was one positive case, which was also published separately, 1 serum anti-B19 IgG was positive in 30% of patients, which is consistent with the population prevalence adjusted for age.…”

mentioning

confidence: 62%

Association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia

Kerr

Barah²,

Cunniffe³

et al. 2003

Journal of Clinical Pathology

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Aims: To investigate the association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia. Methods: Cerebrospinal fluid (CSF) samples from patients with acute myelogenous leukaemia (AML) at diagnosis (n = 2) and acute lymphoblastic leukaemia (ALL) at diagnosis (n = 14) were analysed for parvovirus B19 DNA by means of nested polymerase chain reaction. In addition, samples from patients with benign intracranial hypertension (BIH) (n = 10) and hydrocephalus (n = 13) were tested as controls.Results: Four leukaemia cases were positive-common ALL (n = 2), null cell ALL (n = 1), and M7 AML (n = 1)-whereas all controls were negative (Yates corrected x 2 value, 3.97; p = 0.046; odds ratio, 16.92; confidence interval, 1.03 to 77.18). All four patients were significantly anaemic, but none was encephalitic or had evidence of central nervous system leukaemia. In three of these patients, serum tumour necrosis a, interferon c, interleukin 6, granulocyte-macrophage colony stimulating factor (range, 34.93-3800.06 pg/ml), and macrophage chemoattractant protein 1 were detectable. All of these four patients carried at least one of the HLA-DRB1 alleles, which have been associated with symptomatic parvovirus B19 infection. Conclusion: Erythroid suppression and immune cell proliferation are both associated with B19 infection and may also be important in the pathogenesis of acute leukaemia. P arvovirus B19 is the aetiological agent of erythema infectiosum, transient bone marrow aplastic crises, arthritis, non-immune hydrops fetalis, and chronic pure red cell aplasia in immunocompromised persons. More than 20 reports describe an association between acute lymphoblastic leukaemia (ALL) and persistent B19 infection which, until recently, has been assumed to represent an opportunistic infection, the chronicity of which results from immunosuppression. However, several reports describe B19 infection preceding and mimicking ALL.

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confidence: 62%

Association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia

Kerr

Barah²,

Cunniffe³

et al. 2003

Journal of Clinical Pathology

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“…Certain studies have reported that parvovirus B19 infection is associated with the inhibited status of bone marrow in pre-ALL children (16), and that children infected by parvovirus B19 are more susceptible to severe anemia (17). However, there was no evidence of such viral infection in the present patient.…”

Section: Discussionmentioning

confidence: 99%

Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature

Liang

Ding

et al. 2015

Oncology Letters

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Abstract.A preleukaemic phase, typified by transient pancytopenia, is a rare occurrence that usually affects children and adolescents. The present study reports the case of a 50-yearold woman with transient pancytopenia, which manifested as a fever, cough and severe anemia. Three weeks following treatment of pancytopenia with antibiotics, red blood cell and platelet transfusion, granulocyte colony-stimulating factor and human γ globulin, the condition of the patient was improved. However, 3 weeks following discharge from hospital, the patient was diagnosed with acute lymphoblastic leukemia (ALL) with complex chromosomal abnormalities, including Philadelphia chromosome and P190 breakpoint cluster region-ABL. Complete remission was achieved following one course of combination chemotherapy. In conclusion, adult ALL with pancytopenia as a preceding symptom is rare, difficult to diagnose early and easily misdiagnosed. In addition, the pathogenesis of ALL and the precipitating factors underlying this disease require further investigation.

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“…, 1992; Lee, Kim & Bang, 1994; Sitar et al. , 1999; Heegaard, Madsen & Schmiegelow, 2001; Kerr et al. , 2003; Savasan & Ozdemir, 2003; Yetgin et al.…”

Section: Introductionmentioning

confidence: 99%

Promoter methylation of P15^INK4B gene is possibly associated with parvovirus B19 infection in adult acute leukemias

Yalcin

Serin

Emekdaş

et al. 2009

Int J Lab Hematology

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In this study, we examined the P15(INK4B) gene promoter methylation in patients with myelodysplastic syndrome and acute leukemia and its possible relationship with parvovirus B19 and Epstein-Barr virus infections. P15(INK4B) methylation frequency was significantly higher in acute leukemia patients than in that of non-malignant patients (P < 0.05). When the patients with myelodysplastic syndrome were included, no significant difference was found between these groups regarding the methylation status. The possible correlation between P15(INK4B) promoter methylation and parvovirus B19 infection was observed in adult acute leukemia patients (P < 0.05). However, no similar relationship in EBV-infected patients was observed. To the best of our knowledge, this is the first report showing the possible association between P15(INK4B) promoter methylation and parvovirus B19 infection in acute leukemia.

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Transient pancytopenia preceding acute lymphoblastic leukaemia (pre‐ALL) precipitated by parvovirus B19

Cited by 32 publications

References 19 publications

Association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia

Association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia

Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature

Promoter methylation of P15^INK4B gene is possibly associated with parvovirus B19 infection in adult acute leukemias

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Transient pancytopenia preceding acute lymphoblastic leukaemia (pre‐ALL) precipitated by parvovirus B19

Cited by 32 publications

References 19 publications

Association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia

Association of acute parvovirus B19 infection with new onset of acute lymphoblastic and myeloblastic leukaemia

Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature

Promoter methylation of P15INK4B gene is possibly associated with parvovirus B19 infection in adult acute leukemias

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Promoter methylation of P15^INK4B gene is possibly associated with parvovirus B19 infection in adult acute leukemias