Transient Oromotor Deficits in Children with Benign Childhood Epilepsy with Central Temporal Spikes

Kramer, Uri; Ben‐Zeev, Bruria; Harel, Shaul; Kivity, Shaye

doi:10.1046/j.1528-1157.2001.28700.x

Cited by 19 publications

(16 citation statements)

References 20 publications

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“…Conversely, other studies have shown language dysfunction in children with RE (Deonna et al 1993(Deonna et al , 2000Staden et al 1998). Difficulties in word-retrieval have been reported , Kramer et al 2001 which contradicts the present study in which the Rapid Confrontation Naming test was used. Staden and colleagues (1998) included a dyspraxia screening and this revealed abnormality in nine of 20 children, most frequently concerning lip and tongue movements and difficulties in articulating a sequence of syllables.…”

Section: Discussioncontrasting

confidence: 99%

“…The optimal function of the auditory Oromotor Performance in Rolandic Epilepsy Staffan Lundberg et al 607 perception may be disturbed if there is a maturational dependent dysfunction of essential pathways, including EEG activity. The oromotor dysfunction reported in studies of intense or 'acute' RE (Roulet et al 1989, Boulloche et al 1990, Deonna et al 1993, Kramer et al 2001) was positively correlated with increased bilateral synchronous or asynchronous rolandic discharges. In the present study, bilateral rolandic discharges did not occur synchronously.…”

Section: Discussionmentioning

confidence: 90%

“…Normally, the child with RE has no obvious speech or language problems interfering with their daily life, but some case studies reported more prolonged or repeatedly occurring oromotor dysfunction combined with speech defects. These reports concern children with RE with partial status epilepticus (Fejerman and Di Blasi 1987, Colamaria et al 1991, Septien et al 1992, Fejerman et al 2000, Gregory et al 2002, and RE with abundant paroxysmal bilateral rolandic discharges seen in electroencephalography (EEG), the frequency of which most often correlates with aggravation of the oromotor problems (Roulet et al 1989, Boulloche et al 1990, Deonna et al 1993, Kramer et al 2001). Furthermore, a hereditary disorder with electroclinical features resembling RE and with oral speech dyspraxia has been reported (Scheffer et al 1995).…”

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confidence: 99%

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Children with rolandic epilepsy have abnormalities of oromotor and dichotic listening performance

Lundberg¹,

Frylmark²,

Eeg‐Olofsson³

2005

Dev Med Child Neurol

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Twenty children (11 females; age range 8y 2mo to 14y 7mo, mean 10y 6mo, SD 1y 8mo) with electroclinically typical rolandic epilepsy (RE), were investigated to demonstrate possible occurrence of abnormal oromotor functions and oral sensibility, linguistic problems, and impaired auditory discrimination. Twelve children were treated with an antiepileptic drug (carbamazepine, valproate, or sulthiame). They were compared with an age- and sex-matched control group of 24 children (14 females; age range 8y 2mo to 14y 5mo, mean 11y, SD 1y 8mo). The test battery included tests for facial expressions, lip and tongue movements, repeated syllables, and articulation using nonsense and tongue-twisting words. Sensibility on tongue and lips was tested with two-point discrimination. As language tests, Rapid Confrontation Naming, orthographic, and phonologic decoding tests were used. A dichotic listening test was performed in 13 children with RE and in 14 controls. Compared to control children, those with RE had significantly greater problems concerning tongue movements (p < 0.05) and articulation (nonsense words and tongue-twisting words; p < 0.01), and worse performance on dichotic listening (p < 0.05). Oro-lingual sensibility and results of language tests did not differ between those with RE and control children. The results indicate that children with RE have distinct but mild problems with oromotor performance and auditory discrimination.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 99%

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Children with rolandic epilepsy have abnormalities of oromotor and dichotic listening performance

Lundberg¹,

Frylmark²,

Eeg‐Olofsson³

2005

Dev Med Child Neurol

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“…These three patients resemble those in other sporadic reports of transient neurologic dysfunction of epileptic origin in children with typical BCECTS (1–5,8–11). The clinical presentation was variable and involved a combination of slurred speech, continuous drooling, oromotor dyspraxia, atonic head nods, or facial myoclonia.…”

Section: Discussionsupporting

confidence: 81%

Partial Status Epilepticus in Benign Childhood Epilepsy with Centrotemporal Spikes: Are Independent Right and Left Seizures a Risk Factor?

2002

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Summary:Purpose: To describe an association between continuous simple partial seizures and independent right and left partial seizures in children with benign childhood epilepsy with centrotemporal spikes (BCECTS).Methods: Three children with BCECTS and episodes of continuous simple partial seizures are described.Results: All three children had a history of typical rolandic seizures occurring on the right and left sides of the body on different occasions. Conclusions:The occurrence of independent right and left rolandic seizures in children with BCECTS may be a predisposing factor for the development of partial status epilepticus. Key Words: Benign childhood epilepsy with centrotemporal spikes-oromotor dyspraxia-partial status epilepticusinterictal discharges-operculum syndrome.Continuous partial seizures with drooling, oromotor dyspraxia, head nodding, or twitching of facial muscles have been described in children with benign childhood epilepsy with centrotemporal spikes (BCECTS) (1-4). The clinical episodes occurred at times of increased frequency of bilateral rolandic or diffuse spike discharge (3-5). Although BCECTS is the most common partial epilepsy syndrome in children (6), there have been very few children with BCECTS in whom there were continuous partial seizures (1-4). We describe three children with these clinical features and report the occurrence of independent right and left typical rolandic seizures at different times in all three children. CASE REPORTS Patient 1This 4-year-old boy was the product of a normal pregnancy and delivery. Motor and speech milestones were normal before the seizures. There was a family history of BCECTS in one sibling, speech difficulties in a second sibling, and learning difficulties in the father.Typical simple partial rolandic seizures started at age 2.5 years and occurred monthly until age 3 years. The initial seizure involved jerking of the left side of his face for 1-2 min with preserved consciousness and postictal dysarthria. On one occasion, a seizure characterized by twitching of the child's face with no loss of consciousness was followed by a right Todd's paresis, which lasted several minutes. He had a secondarily generalized seizure at age 3 years, lasting 5 min. This seizure occurred on falling asleep and began with right facial twitching. Neurologic examination 1 month later demonstrated deviation of the tongue to the right on protrusion and difficulty copying tongue or facial movements, such as sucking on a straw. Brain computed tomography (CT) and magnetic resonance imaging (MRI) scan were normal. Treatment with carbamazepine (CBZ) was associated with seizure control for 7 months.After a chickenpox infection, the seizures recurred and increased over a 2-week period to eight seizures per day. The seizures involved episodes of continuous drooling and dysarthria associated with occasional jerks of either side of the face, poor head control, and a left hemiparesis. There was no loss of consciousness, but the child did not recover neurologic function completely ...

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“…Other atypical forms of BCECTS include benign childhood epilepsy with centrotemporal spikes with frequent refractory seizures (Lerman & Kivity, 1975; Loiseau et al., 1988; Kramer et al., 2002), the “classic” atypical variant of BCECTS (Aicardi & Chevrie, 1982; Fejerman et al., 2000), status epilepticus of BCECTS (Fejerman & Di Blasi, 1987), BCECTS with transient oromotor dysfunction (Roulet et al., 1989; Deonna et al., 1993; Kramer et al., 2001; Dubois et al., 2003), and BCECTS presenting as falls (Watemberg et al., 2009). The “classic” atypical form usually presents as severe aggravation, but in contrast to ESES and LKS, the cognitive outcome is always favorable (Fejerman et al., 2007).…”

Section: Atypical Formsmentioning

confidence: 99%

The prevalence of atypical presentations and comorbidities of benign childhood epilepsy with centrotemporal spikes

et al. 2011

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Summary Purpose: Benign childhood epilepsy with centrotemporal spikes (BCECTS) is the most common epileptic syndrome in childhood. The outcome is usually excellent, but there are some atypical forms of BCECTS with less favorable outcomes. The aim of this study was to delineate the frequency of these atypical features among patients with BCECTS. Methods: We conducted a retrospective chart study by retrieving the medical records of all consecutive patients with BCECTS who were evaluated in four pediatric neurology outpatient clinics in Israel between the years 1991 and 2008. Key Findings: A total of 196 patients with BCECTS were identified (78 female and 118 male; mean age at time of diagnosis 7.64 years, range 1.5–14). The mean duration of follow‐up was 4.43 years (range 2–11). Nine patients (4.6%) developed electrical status epilepticus in slow waves sleep (ESES) during follow‐up, four (2%) had Landau‐Kleffner syndrome, three (1.5%) had BCECTS with frequent refractory seizures, two (1%) had BCECTS with falls at presentation, one (0.5%) had a “classic” atypical variant, and one (0.5%) had oromotor dysfunction. None had rolandic status epilepticus. Sixty‐one patients (31%) had attention deficit hyperactivity disorder (ADHD), 43 (21.9%) had specific cognitive deficits, and 23 (11.7%) had behavioral abnormalities, including aggressiveness, anxiety disorders, depression, and pervasive developmental disorder (PDD). Significance: The prevalence of most atypical forms of BCECTS other than ESES is low. There is, however, a high prevalence of ADHD and specific cognitive deficits among patients with BCECTS.

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Transient Oromotor Deficits in Children with Benign Childhood Epilepsy with Central Temporal Spikes

Cited by 19 publications

References 20 publications

Children with rolandic epilepsy have abnormalities of oromotor and dichotic listening performance

Children with rolandic epilepsy have abnormalities of oromotor and dichotic listening performance

Partial Status Epilepticus in Benign Childhood Epilepsy with Centrotemporal Spikes: Are Independent Right and Left Seizures a Risk Factor?

The prevalence of atypical presentations and comorbidities of benign childhood epilepsy with centrotemporal spikes

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