Transient Optic Perineuritis as the Initial Presentation of Central Nervous System Involvement by Pre-B Cell Lymphocytic Leukemia

Townsend, Justin H.; Dubovy, Sander R.; Pasol, Joshua; Lam, Byron L.

doi:10.1097/wno.0b013e318281b84d

Cited by 24 publications

(22 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of cases are isolated and idiopathic [1,2]. Syphilis, Wegener's granulomatosis, sarcoidosis, Crohn disease and leukemia have been reported as causing optic perineuritis in adult patients [3][4][5][6][7][8]. Based on a PubMed literature search, limited information is available regarding optic perineuritis in pediatric patients.…”

Section: Introductionmentioning

confidence: 99%

A unilateral optic perineuritis in a teenager – A case report

Ameilia

Shatriah

Hitam

et al. 2015

Brain and Development

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

A unilateral optic perineuritis in a teenager – A case report

Ameilia

Shatriah

Hitam

et al. 2015

Brain and Development

View full text Add to dashboard Cite

“…It is a great mimicker of typical ON. OPN has been reported mostly as idiopathic and isolated cases [1] although associations with other diseases such as Wegener granulomatosis [2], giant cell arteritis [3], Crohn’s disease [4], Behcet disease [5], leukemia [6] and acute retinal necrosis [7] have been reported. To the best of our knowledge, there are limited reports of OPN in patients with NMO or NMOSD.…”

Section: Discussionmentioning

confidence: 99%

Optic Perineuritis in Neuromyelitis Optica Spectrum Disorder

Kamaluddin

Tai

Hitam

et al. 2019

Cureus

View full text Add to dashboard Cite

Optic perineuritis (OPN) involvement in demyelinating disease is rarely encountered. To our knowledge, this is the first reported case of bilateral OPN associated with neuromyelitis optica spectrum disorder (NMOSD). We present a case of a healthy young gentleman who presented with OPN, initially presumed to have a young stroke but later diagnosed to be NMOSD. Early neuroimaging is essential to help distinguish optic neuritis (ON), and prolonged treatment of systemic immunosuppression is the mainstay of treatment.

show abstract

“…Similarly, in our series, 4 of 5 patients with leukemic infiltration of optic nerve achieved complete remission and had no previous history of central nervous system involvement. Due to their low prevalence, only a few literatures have addressed the MR imaging findings of leukemic infiltration of optic nerve (6,(8)(9)(10)(11)(12)(13). A search of the literature in English showed 6 cases of leukemic infiltrations of optic nerve (Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…A search of the literature in English showed 6 cases of leukemic infiltrations of optic nerve (Table 3). MR imaging finding of the leukemic infiltration of optic nerve is thickening of the optic nerve with enhancement (6,(8)(9)(10)(11)(12)(13). Enhancing optic nerve thickening is also noted in patients with optic neuritis, however, no case of optic neuritis in leukemic patient has been reported yet.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Enhancement of Optic Nerve in Leukemic Patients: Leukemic Infiltration of Optic Nerve versus Optic Neuritis

Han

Park

et al. 2016

Investig Magn Reson Imaging

View full text Add to dashboard Cite

Original ArticlePurpose: To identify magnetic resonance imaging (MRI) findings of leukemic infiltration of optic nerve and optic neuritis in leukemic patients with emphasis of clinical findings as reference standard to differentiate them. Materials and Methods: MRI and clinical findings of 7 patients diagnosed as leukemic infiltration of optic nerve (n = 5) and optic neuritis (n = 2) in our institution between July 2006 and August 2015were reviewed retrospectively. In particular, MR imaging findings involved perineural enhancement and thickening of optic nerve and its degree, signal intensity, laterality (unilateral/bilateral), intraconal fat infiltration and its degree, and associated central nervous system abnormalities. Results: Of 5 cases of leukemic infiltration of optic nerve, 4 cases showed positive cerebrospinal fluid (CSF) study for leukemia relapse and 1 case was positive on bone marrow (BM) biopsy only. Moreover, of 5 leukemic infiltration of optic nerve, 2 cases showed the most specific MR findings for leukemic central nervous system involvement including 1 prominent leptomeningeal enhancement and 1 chloroma. However, other MR imaging findings of the patients with leukemic infiltration or optic neuritis such as thickening and perineural enhancement of optic nerves are overlapped. Conclusion: Enhancement and thickening of optic nerve were overlapped MR findings in leukemic infiltration of optic nerve and optic neuritis. Our findings suggest that enhancing optic nerve thickening with associated central nervous system MR abnormality favors the diagnosis of leukemic infiltration of optic nerve, especially in patients with history of acute lymphoblastic leukemia. However, CSF and BM study were required for differentiation between leukemic infiltration of optic nerve and optic neuritis.

show abstract

Transient Optic Perineuritis as the Initial Presentation of Central Nervous System Involvement by Pre-B Cell Lymphocytic Leukemia

Cited by 24 publications

References 15 publications

A unilateral optic perineuritis in a teenager – A case report

A unilateral optic perineuritis in a teenager – A case report

Optic Perineuritis in Neuromyelitis Optica Spectrum Disorder

Enhancement of Optic Nerve in Leukemic Patients: Leukemic Infiltration of Optic Nerve versus Optic Neuritis

Contact Info

Product

Resources

About