The Cochrane Database of Systematic Reviews (Complete Reviews) 2005
DOI: 10.1002/14651858.cd003006.pub2
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Transient neurologic symptoms (TNS) following spinal anaesthesia with lidocaine versus other local anaesthetics

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Cited by 42 publications
(48 citation statements)
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“…The cause of this painful complication is as yet unknown and none of the speculations on its origin have been substantiated [3]. Previous studies indicated TNS to be a substance-specific effect, neither concentration nor dose dependent [7,8].…”
Section: Discussionmentioning
confidence: 96%
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“…The cause of this painful complication is as yet unknown and none of the speculations on its origin have been substantiated [3]. Previous studies indicated TNS to be a substance-specific effect, neither concentration nor dose dependent [7,8].…”
Section: Discussionmentioning
confidence: 96%
“…We performed a power analysis according to the Cochrane review of Zaric and Pace [3] assuming 0.2 % for prilocaine and 10 % for mepivacaine as TNS proportions. With alpha = 0.05 and power = 0.80 we assessed a total sample size of 156.…”
Section: Statisticsmentioning
confidence: 99%
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“…So many authors tried to optimize the dosage and concentration of bupivacaine for ambulatory knee surgery, but achieved only a recovery profile comparable to GA [8][9][10]. In 2010, after introduction of hyperbaric prilocaine 2% to the German market, a medium-long acting local anesthetic with pharmacological characteristics comparable to lidocaine and mepivacaine but a remarkable lower incidence of TNS, a nearly perfect substance for this indication seemed to be available [11]. We assumed that due to a shorter duration of action of prilocaine compared to bupivacaine, a SPA could lead to a faster recovery than a GA.…”
Section: Introductionmentioning
confidence: 99%