Transient myocarditis associated with acute Zika virus infection

Aletti, M.; Lecoules, S.; Kanczuga, V.; Soler, C.; Maquart, Marianne; Simon, Fabrice; Leparc-Goffart, Isabelle

doi:10.1093/cid/ciw802

Cited by 38 publications

(41 citation statements)

References 7 publications

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“…Humoral and cell-mediated immunity assays demonstrated robust responses in the setting of this infection. The immunologic milieu in our patient differs from that of adult patients in whom prior flavivirus infection and/or vaccination are common, and it also differs from the case report of myocarditis, in which the individual had evidence of a previous DENV infection [9]. Our case indicates that cardiac manifestations may occur in flavivirus-naive individuals as well as those with previous flavivirus exposure.…”

Section: Discussioncontrasting

confidence: 62%

Pericarditis Associated With Acute Zika Virus Infection in a Returning Traveler

Waggoner

Rouphael

et al. 2017

Open Forum Infectious Diseases

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Section: Discussioncontrasting

confidence: 62%

Pericarditis Associated With Acute Zika Virus Infection in a Returning Traveler

Waggoner

Rouphael

et al. 2017

Open Forum Infectious Diseases

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“…Arboviruses other than Zika are known to cause myocarditis and pericarditis [18,19], and viral antigen detection has been confirmed in myocardium and endothelial cells, so it is plausible that ZIKV infection could also cause heart disease. In fact, the inoculation of mice with ZIKV strains led to myocarditis [20], and myocarditis was also reported in a human case of ZIKV infection [21]. Cardiac involvement in our patient could be the result of heavy early gestational viremia during a vulnerable period of morphogenesis, even though an association between ZIKV infection and cardiac defects has yet to be proven.…”

Section: Discussionsupporting

confidence: 51%

Is There More to Zika? Complex Cardiac Disease in a Case of Congenital Zika Syndrome

Angelidou¹,

Michael²,

Hotz³

et al. 2017

Neonatology

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The epidemic of Zika virus (ZIKV) has resulted in a surge of newborns with microcephaly and brain abnormalities. In this report, we describe the first case, to our knowledge, of congenital Zika syndrome with concomitant critical congenital heart disease. The mother had a confirmed ZIKV infection in the first trimester of pregnancy. Fetal ultrasonography at 31 weeks of gestation revealed cerebral cortical calcifications and hypoplastic left heart syndrome. The severity of brain involvement was assessed by postnatal magnetic resonance imaging and echocardiogram, and palliative surgery was performed. The ethical dimensions of this infant's clinical management are discussed. ZIKV is known to affect neural progenitor cells, but whether it could have a tropism for other tissues remains unclear.

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“…Since it has already been established that similar arboviral diseases, such as chikungunya and dengue, have acute myocardial implications [ 15 ], it was suggested that due to the smaller size of the ZIKV, the virus also has the ability to invade cardiac cells [ 16 ]. Owing to the recent state of emergency that the virus has created [ 17 ] and the lack of time lapse since then [ 18 ], the effects that ZIKV may have on cardiac cells have been overlooked [ 19 ]. Our study aims to draw attention towards this untapped, yet clinically important feature of ZIKV.…”

Section: Introductionmentioning

confidence: 99%

Association of Zika Virus with Myocarditis, Heart Failure, and Arrhythmias: A Literature Review

Minhas¹,

Nayab²,

Iyer³

et al. 2017

Cureus

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As the concerns regarding Zika virus (ZIKV) are mostly of neurological disorders, especially in neonates and infants, other possible threats of the virus may have been overlooked. Our study focuses on the potential threat that ZIKV may pose to the heart like that of similar arboviral diseases. We conducted a literature search of multiple terms in March 2017 using the search engines, PubMed, Embase, and SCOPUS. Articles were then reviewed by two independent reviewers, adhering strictly to our review criteria. No discriminations were made whether the studies were conducted on human or non-human subjects. Three relevant studies were shortlisted and finalized. The nature of the studies is as follows: prospective observational multicenter study (n = 9), case report (n = 1), and animal studies (n = 5). The studies suggested an association between cardiovascular complications and ZIKV in the acute phase of the infection. We recognize the limitations of our study owing to the paucity of the sample size of our literature review. However, the significant findings have also proved the dire need to conduct more research to further back the possibility of ZIKV’s influence on the cardiac cells. Closely studying these associations can eventually help develop a vaccine for ZIKV in the near future.

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Transient myocarditis associated with acute Zika virus infection

Cited by 38 publications

References 7 publications

Pericarditis Associated With Acute Zika Virus Infection in a Returning Traveler

Pericarditis Associated With Acute Zika Virus Infection in a Returning Traveler

Is There More to Zika? Complex Cardiac Disease in a Case of Congenital Zika Syndrome

Association of Zika Virus with Myocarditis, Heart Failure, and Arrhythmias: A Literature Review

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