Air brake system is one of the common braking methods for buses and trucks; its excellent performance guarantees the safety of the vehicle and the stability of the braking. As an important part of the pneumatic brake system, the brake pipe is an important factor influencing the pressure response time of the pneumatic brake system. Based on the exploratory experiment of pneumatic brake pipe, the influence of pipe length, pipe diameter, inlet sonic conductance, initial pressure, and supply pressure on pipe pressure response time was analyzed by fuzzy gray correlation analysis method. The results show that tube length is the most important factor affecting the pressure response time. Combined with the analysis results of gray correlation degree, the experimental scheme of the response time of the pneumatic brake pipe was designed by the response surface experimental design method. Based on the multiparameter analysis method, the influence of the experimental parameters on the pipe pressure response time was analyzed. Based on the experimental data, the form of calculation formula is derived by dimension analysis method, which provides a theoretical basis for the selection of pneumatic brake pipes and the design of air brake system.