Transient Lymphopenia Of Infancy: A Previously Unrecognized Entity

Sporter, Robert; Capo, Catherine; Bonagura, V.R.

doi:10.1016/j.jaci.2013.12.822

Cited by 2 publications

(1 citation statement)

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“…The evaluation of low TRECs has led to the diagnosis of some true primary and secondary immune deficiencies but has also led to the discovery of an entity referred to as idiopathic or transient T cell lymphopenia of infancy. 23,27,28 These infants do not appear to be prone to increased infection, and the T cells return to normal by a year of life. This is thought to be analogous to transient hypogammaglobulinemia, and the lack of recognition prior to NBS suggests it is a benign condition.…”

Section: Transient T-cell Lymphopenia Of Infancymentioning

confidence: 99%

Conditions Other than Severe Combined Immune Deficiency Found on SCID Newborn Screening

Freij

2022

MRAJ

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Severe combined immune deficiency (SCID) is caused by a wide variety of genetic variants that result in absent or diminished levels of mature and functional T cells. SCID Newborn Screening programs that detect T cell receptor excision circles have resulted in early intervention and improvement in survival rates in infants with SCID but have also identified other conditions with low T cells. These conditions trigger what could be thought of as false positive tests for SCID, but for the most part they do reflect low T cells in conditions other than SCID. The scope of this review is entities other than severe combined immune deficiency that cause low T cell receptor excision circles (TRECs) and are thus identified on newborn screening. Secondary immune deficiencies from prematurity, neonatal medical conditions, hypomorphic or incomplete variants of SCID, transient T cell lymphopenia of infancy, and primary immune deficiencies that do not qualify as SCID are all elaborated. Identification and treatment options for these conditions leading to low TRECs are discussed.

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Section: Transient T-cell Lymphopenia Of Infancymentioning

confidence: 99%