Transient Lesion of the Splenium of the Corpus Callosum after Acute Ischemic Stroke

Yamaguchi, Yoshitaka; Iwasaki, Yuko; Wada, Manabu; Makita, Naoki; Nagasawa, Hikaru; Yamakawa, Tatsushi; Toyoda, Kazunori

doi:10.2169/internalmedicine.1010-18

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…In addition to infection, MERS has also been reported to be associated with epilepsy and the use of antiepileptic drugs (Maeda et al, 2003;Mirsattari, Lee, Jones, & Blume, 2003). Extant literature has reported the other potential causes including substance withdrawal, metabolic disturbance, drug-related toxicity, malignancies, cerebrovascular diseases, traumatic brain injury, status migrainosus, and high-altitude disease (altitude sickness) (Al Brashdi & Albayram, 2015;Bin & Lee, 2011;Garcia-Monco et al, 2011;Kallenberg et al, 2007;Kim & Gean, 2011;Maeda et al, 2006;Park et al, 2017;Renard, Bonafe, & Heroum, 2007;Samanta, 2015;Starkey, Kobayashi, Numaguchi, & Moritani, 2017;Takanashi et al, 2009;Takayama, Kobayashi, Sugishita, & Mihara, 2000;Tha et al, 2002;Yamaguchi et al, 2019). A listing is provided in Table identified the etiologies for 30 cases including cerebral infarction (50%), trauma (13.3%), tumor (10%), alcohol abuse (6.7%), seizure (6.7%), heat stroke (3.3%), multiple sclerosis (3.3%), drug intoxication (3.3%), and panhypopituitarism (3.3%).…”

Section: Splenium Of the Corpus Callosum Lesions Demonstrated On Mri Inmentioning

confidence: 99%

Reversible lesion in the splenium of the corpus callosum

Tetsuka

2019

Brain and Behavior

107

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Aim of Review The presence of isolated, reversible lesions in the splenium of the corpus callosum (SCC) is essential to confirm the diagnosis of mild encephalitis/encephalopathy. The lesions usually heal within a month after the onset of neurological symptoms. Magnetic resonance imaging (MRI) has increasingly been used as a diagnostic tool, which has led to the publication of an increasing number of case reports. These have highlighted some inconsistencies about encephalitis/encephalopathy. First, the condition is not always mild and may be severe. Second, reversible lesions in the SCC have been identified in various diseases and conditions other than viral encephalitis/encephalopathy. Third, lesions in SCC are not always completely reversible. On this note, this review describes the specific clinical and radiological features of encephalitis/encephalopathy. Findings The reversible lesion in SCC is an MRI finding observable in a wide variety of diseases and conditions. Thus, it should be considered as a secondary change rather than a peculiar feature associated with mild encephalitis/encephalopathy. If reversible lesions are present in the SCC, the symptoms and prognosis are not necessarily favorable, with manifestations of encephalitis/encephalopathy varying from absent to severe. Neuroradiological features that appear as isolated high‐intensity signals on diffusion‐weighted images and a decreased apparent diffusion coefficient of the lesion might indicate a diagnosis of cytotoxic edema. Findings of previous studies suggest that cytokine‐mediated cytotoxic edema of the SCC may be an important pathophysiological manifestation of this condition. Conclusion The reversible lesions in the SCC found on MRI are not exclusive to encephalitis/encephalopathy but may be secondary to other disorders.

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Section: Splenium Of the Corpus Callosum Lesions Demonstrated On Mri Inmentioning

confidence: 99%

Reversible lesion in the splenium of the corpus callosum

Tetsuka

2019

Brain and Behavior

107

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“…The most common location of CC infarction is the splenium, but pure splenial infarction is rare. Because of the well-developed collateral circulation, CC infarction usually accompanies with additional lesion due to large vessel occlusion [2,7]. Therefore, there have been only 10 previous reports of pure splenium infarction [3,[8][9][10][11][12][13][14][15][16] without any other lesions in the cortex nor optic tract (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Homonymous Hemianopsia Due to the Infarction in the Splenium of the Corpus Callosum

Katsuki¹,

Kato²,

Niizuma³

et al. 2021

Cureus

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The precise functions of the splenium of the corpus callosum (CC) remain unclear, and infarction of this location manifests varied clinical symptoms. We describe a rare case of right homonymous hemianopsia resulting from pure infarction in the right-side splenium of the CC. An 85-year-old man presented with right homonymous hemianopsia lasting for a week. Diffusion-weighted imaging showed a high-intensity area in the right-side splenium of the CC and did not show any other lesions in other portions of the visual pathways. Magnetic resonance angiography demonstrated anterior and posterior cerebral arteries, indicating that no large vessel occlusion existed. The visual field examination revealed right homonymous hemianopsia. The diagnosis was atherothrombotic infarction in the splenium of the CC, which resulted in right homonymous hemianopsia. Two months later, T2-weighted imaging showed a high-intensity lesion localizing the right-side splenium with shrinkage of the lesion compared to that on the acute phase, and his visual field was slightly improved. There are few reports on the splenial infarction of the CC, and this is the first case manifesting as homonymous hemianopsia, to our knowledge. Our case might help to understand complicated visual information processing involving the splenium of the CC.

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Treatment-related transient splenial lesion of the Corpus Callosum in patients with neuropsychiatric disorders: a literature overview with a case report

Cirnigliaro

Bernardo

Caricasole

et al. 2020

Expert Opinion on Drug Safety

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Q1Introduction: Transient-localized © lesions of the splenium of the corpus callosum (SCC) have been described in various clinical conditions, some of them being attributed to the withdrawal of psychotropic drugs. The pathophysiology of the lesion likely reflects cytotoxic edema and reversible demyelination.Areas covered: The present article aimed at reviewing cases of transient SCC lesion exclusively related to changes in pharmacological treatment. It also reports the original case of a psychotic patient receiving a complex psychopharmacological therapy who developed a transient SCC lesion investigated by magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), © and pharmacogenetic profiling. Expert opinion: To date, only one review on the subject has been published, analyzing 22 cases of transient SCC lesion arising in epileptic patients on antiepileptic therapy. It hypothesized that the nature of the lesion is a cytotoxic edema and the cases described in the subsequent 14 years seem to support this hypothesis. The authors reported the case of an Italian-Egyptian patient who developed a transient SCC lesion after the rapid withdrawal of Carbamazepine and Lurasidone. The lesion completely disappeared from the MRI performed after 1 month © . Patient's ethnic group and its specific pharmacogenetic profile were considered as possible causes of altered drug metabolism and, likely, of the SCC lesion. Q2 ARTICLE HISTORY

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Transient Lesion of the Splenium of the Corpus Callosum after Acute Ischemic Stroke

Cited by 5 publications

References 15 publications

Reversible lesion in the splenium of the corpus callosum

Reversible lesion in the splenium of the corpus callosum

Homonymous Hemianopsia Due to the Infarction in the Splenium of the Corpus Callosum

Treatment-related transient splenial lesion of the Corpus Callosum in patients with neuropsychiatric disorders: a literature overview with a case report

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