Abstract:Association of protease inhibitors and ergotamine causing systemic ergotism is well established 1,2,3 . Cerebral ergotism is poorly reported 4,5 . We describe the case of an HIV positive 49 yo man under protease inhibitors (ritonavir) presenting with total reversible left hemiparesis after the intake of 3 g of ergotamine. After 20 minutes he was spontaneously asymptomatic. TIA was diagnosed. Parenchymal MRI was normal, cervical doppler ultrasound showed symmetric narrowing in both internal carotid arteries, ca… Show more
“…Carotid involvement is uncommon but it has been described. 5 Septicemia, as in the case reported, can increase the vasoconstrictor effect of ergotamine. 2 Treatment involves discontinuation of ergot medication and, in severe cases, the use of vasodilators, including prostaglandin E or methylprednisolone as second-line therapy.…”
Funding information and disclosures are provided at the end of the article. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp. PRACTICAL IMPLICATIONS Consider that ergotism can occur without abusive consumption of ergotic drugs due to pharmacologic interaction or interaction with dietary foods or other natural products.
“…Carotid involvement is uncommon but it has been described. 5 Septicemia, as in the case reported, can increase the vasoconstrictor effect of ergotamine. 2 Treatment involves discontinuation of ergot medication and, in severe cases, the use of vasodilators, including prostaglandin E or methylprednisolone as second-line therapy.…”
Funding information and disclosures are provided at the end of the article. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp. PRACTICAL IMPLICATIONS Consider that ergotism can occur without abusive consumption of ergotic drugs due to pharmacologic interaction or interaction with dietary foods or other natural products.
“…The patient became asymptomatic after a week. (Gaye-Saavedra et al, 2016) The cases reported for Ergot are presented in detail in Table 1, as below;…”
Ergot alkaloids produced by the fungus Claviceps parasitizing on cereals presents a high toxicity risk for animals and humans due to presence of its alkaloid content. Ergot-alkaloid toxicity occurs via their medicinal use however human poisoning from ergot plant is rare. The aim of this review is to determine the toxicity of ergot plant or ergotamine derivatives in humans. Databases such as Google scholar, PubMed, Scopus, Web of Science alongwith related books and theses as well as the library resources from Imam Abdulrahman Bin Faisal University were used whereas the Key words searched included; Ergot, Egotism, Ergotamine poisoning, Ergotamine interaction with HIV therapy, Ergotamine overdose, and report cases of ergotism. The relevant literature search suggests many toxicity cases and side effects associated with the use of ergot-alkaloids. More commonly it develops a condition known as ergotism i.e. a disease or toxic condition produced by eating ergot grains or rye or chronic use of ergot drug. The characteristic
ARTICLE INFORMATION:Raghad Al-Omari et al.features of ergotism consist of painful and cold extremities. Furthermore, a notable and severe interaction of ergotalkaloids was found in HIV patients using ergotamine and antiretroviral drugs together. Ergotamine which is one of ergot preparation has poisonous effect when taken in over dose and it interacts with antiretroviral drugs also.
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