Transient Hypoplastic Anemia Caused by Primary Human Parvovirus B19 Infection in a Previously Untreated Patient With Hemophilia Transfused With a Plasma-Derived, Monoclonal Antibody-Purified Factor VIII Concentrate

Allogeneic bone marrow transplantation in a child with severe aplastic anemia and hemophilia A

“…4 Transient hypoplastic anemia has been described in patients with hemophilia, and was related to human parvovirus-B19 infection transmitted by clotting factor concentrates. 2,3 Our patient developed severe aplastic anemia, but no evidence of a viral etiology was found despite extensive investigations.…”

“…Hypoplastic anemia has been described in patients with hemophilia, and is usually associated with human parvovirus-B19 infection. 2,3 We describe the case of a young boy with congenital hemophilia A and acquired severe aplastic anemia (SAA), who was successfully treated by allogeneic bone marrow transplantation (allo-BMT) with his unaffected brother as donor.…”

Different susceptibility of B19 virus and mice minute virus to low pH treatment

“…Despite increased awareness of B19V transmission through blood products, such events recently still occurred 13‐16 . Nevertheless, the concerned products were mainly clotting factor concentrates.…”

“…The challenge that B19V poses for plasma‐derived products and transfusion is due to its resistance to commonly used inactivation measures, its small size, and the high viremia. Despite efforts taken to reduce the risk of B19V transmission through blood products, such events still occurred recently 13‐16 …”

Parvovirus B19 transmission by a high‐purity factor VIII concentrate

“…Consistent with these findings, almost all persons with hemophilia in cross‐sectional studies from 1982 to 1997 were found to be anti‐B19 IgG–positive, in contrast to approximately 50 percent of the untransfused, untreated control population 12 . Reports of transmissions attributed to infused factor VIII (FVIII) concentrates (antihemophilic factor [human][AHF]), subjected to solvent/detergent (S/D) or heat treatment or both, have been numerous 12‐17 …”