Transient hyperglycemia in Hispanic children with acute lymphoblastic leukemia

Abstract

The incidence of chemotherapy-induced transient hyperglycemia in the present study cohort is comparable to that reported in previous pediatric ALL patients. This finding is interesting in view of the elevated prevalence of obesity and the underlying dietary behaviors in this Hispanic study cohort.

Risk Factors for Hyperglycemia During Chemotherapy for Acute Lymphoblastic Leukemia Among Taiwanese Children

“…[5][6][7]12,13 However, several conflicting results in more recent studies have indicated the absence of significant associations between weight status and hyperglycemic episodes. 8,[14][15][16] Given the rising rate of obesity and overweight among Taiwanese children, in the past ten years, those who receive treatment for leukemia may be at a higher risk for secondary hyperglycemia.…”

“…4,5 Hyperglycemia is a common occurrence in pediatric patients during induction chemotherapy of ALL. [6][7][8] The potential causes may include beta cell dysfunction caused by chemotherapeutic drugs such as L-asparaginase, increased insulin resistance and hepatic gluconeogenesis induced by corticosteroids, or synergistic effects of these medications, given that these pharmacological agents are usually combined during initial induction therapy. 4,5 The spectrum of hyperglycemia can range widely from transient isolated episodes to severe life-threatening complications such as diabetic ketoacidosis or non-ketotic hyperglycemic hyperosmolar syndrome.…”

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

“…[8][9][10] Small series suggest that DS-ALL patients have an increased risk of mucositis from methotrexate (MTX), myelosuppression from anthracyclines, and hyperglycemia from glucocorticoids. [10][11][12][13][14][15][16] Acquired leukemic cell genetic abnormalities have important prognostic significance in non-DS childhood ALL. 17 However, the impact of these abnormalities on treatment outcome in DS-ALL is unknown, because all published series lack a sufficient sample size to draw clear conclusions.…”

Diabetes and Metabolic Syndrome in Survivors of Childhood Cancer

“…While steroid-induced transient hyperglycemia in children with cancer often resolves after cessation of therapy [44-46], prolonged hyperglycemia with progression to permanent diabetes has been reported [47]. In a study of diabetes risk among 8,599 childhood cancer survivors, exposure to corticosteroids was associated with an increased prevalence of diabetes in univariate analysis but not in multivariate analysis [9].…”